Cover Image

Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder

Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate...

Full description

Saved in:
Bibliographic Details
Main Authors: Nazree, Nur Elia, Mohamed, Zahurin, Reynolds, Gavin P., Mohd Zain, Shamsul, Masiran, Ruziana, Sidi, Hatta, Lu, Ann Chong, Anne, Yee Hway, Adlan, Aida Syarinaz, Zainal, Nor Zuraida
Format: Article
Language:English
Published: Wiley 2015
Online Access:http://psasir.upm.edu.my/id/eprint/43881/1/Association%20of%20brain-derived%20neurotrophic%20factor%20valine%20to%20methionine%20polymorphism%20.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:psasir.upm.edu.my:43881
record_format eprints
spelling oai:psasir.upm.edu.my:43881 http://psasir.upm.edu.my/id/eprint/43881/ Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder Nazree, Nur Elia Mohamed, Zahurin Reynolds, Gavin P. Mohd Zain, Shamsul Masiran, Ruziana Sidi, Hatta Lu, Ann Chong Anne, Yee Hway Adlan, Aida Syarinaz Zainal, Nor Zuraida Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population. Methods: This is a cross-sectional study. A total of 95 female patients with MDD who met the criteria of the study were recruited and were specifically assessed on the sexual function by trained psychiatrists. Patients' DNA was genotyped for BDNF Val66Met polymorphism using real-time polymerase chain reaction. Results: The prevalence of FSD in this study is 31.6%. In the FSD group, patients with problematic marriage were significantly more frequent compared with patients who did not have problematic marriage (P=0.009). Significant association was detected in the lubrication domain with BDNF Val66Met polymorphism (P=0.030) using additive genetic model, with even stronger association when using the recessive model (P=0.013). Discussion: This study suggested that there was no significant association between BDNF Val66Met with FSD. However, this polymorphism is significantly associated with lubrication disorder in patients treated with SSRIs. Wiley 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43881/1/Association%20of%20brain-derived%20neurotrophic%20factor%20valine%20to%20methionine%20polymorphism%20.pdf Nazree, Nur Elia and Mohamed, Zahurin and Reynolds, Gavin P. and Mohd Zain, Shamsul and Masiran, Ruziana and Sidi, Hatta and Lu, Ann Chong and Anne, Yee Hway and Adlan, Aida Syarinaz and Zainal, Nor Zuraida (2015) Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder. Asia Pacific Psychiatry. ISSN 1758-5864; ESSN: 1758-5872 10.1111/appy.12210
institution UPM IR
collection UPM IR
language English
description Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population. Methods: This is a cross-sectional study. A total of 95 female patients with MDD who met the criteria of the study were recruited and were specifically assessed on the sexual function by trained psychiatrists. Patients' DNA was genotyped for BDNF Val66Met polymorphism using real-time polymerase chain reaction. Results: The prevalence of FSD in this study is 31.6%. In the FSD group, patients with problematic marriage were significantly more frequent compared with patients who did not have problematic marriage (P=0.009). Significant association was detected in the lubrication domain with BDNF Val66Met polymorphism (P=0.030) using additive genetic model, with even stronger association when using the recessive model (P=0.013). Discussion: This study suggested that there was no significant association between BDNF Val66Met with FSD. However, this polymorphism is significantly associated with lubrication disorder in patients treated with SSRIs.
format Article
author Nazree, Nur Elia
Mohamed, Zahurin
Reynolds, Gavin P.
Mohd Zain, Shamsul
Masiran, Ruziana
Sidi, Hatta
Lu, Ann Chong
Anne, Yee Hway
Adlan, Aida Syarinaz
Zainal, Nor Zuraida
spellingShingle Nazree, Nur Elia
Mohamed, Zahurin
Reynolds, Gavin P.
Mohd Zain, Shamsul
Masiran, Ruziana
Sidi, Hatta
Lu, Ann Chong
Anne, Yee Hway
Adlan, Aida Syarinaz
Zainal, Nor Zuraida
Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
author_facet Nazree, Nur Elia
Mohamed, Zahurin
Reynolds, Gavin P.
Mohd Zain, Shamsul
Masiran, Ruziana
Sidi, Hatta
Lu, Ann Chong
Anne, Yee Hway
Adlan, Aida Syarinaz
Zainal, Nor Zuraida
author_sort Nazree, Nur Elia
title Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
title_short Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
title_full Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
title_fullStr Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
title_full_unstemmed Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
title_sort association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
publisher Wiley
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/43881/1/Association%20of%20brain-derived%20neurotrophic%20factor%20valine%20to%20methionine%20polymorphism%20.pdf
_version_ 1819296602460782592
score 13.4562235

Similar Items