Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study

This study examined the associations of diabetes-related distress (DRD), depressive symptoms, health-related quality of life (HRQoL), and medication adherence with glycemia, blood pressure (BP), and lipid biomarkers in adults with type 2 diabetes mellitus (T2D). This cross-sectional study was conduc...

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Main Authors: Chew, Boon How, Mohd Sidik, Sherina, Hassan, Noor Hasliza
Format: Article
Language:English
Published: Dove Medical Press 2015
Online Access:http://psasir.upm.edu.my/id/eprint/43885/1/Association%20of%20diabetes-related%20distress%2C%20depression%2C%20medication%20adherence%2C%20and%20health-related%20quality%20of%20life%20with%20glycated%20hemoglobin%2C%20blood%20pressure%2C%20and%20lipids%20in%20adult%20patients%20with%20type%202.pdf
id oai:psasir.upm.edu.my:43885
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spelling oai:psasir.upm.edu.my:43885 http://psasir.upm.edu.my/id/eprint/43885/ Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study Chew, Boon How Mohd Sidik, Sherina Hassan, Noor Hasliza This study examined the associations of diabetes-related distress (DRD), depressive symptoms, health-related quality of life (HRQoL), and medication adherence with glycemia, blood pressure (BP), and lipid biomarkers in adults with type 2 diabetes mellitus (T2D). This cross-sectional study was conducted in three Malaysian public health clinics in 2012–2013, recruited adult patients (aged ≥30 years) with T2D who had been diagnosed for more than one year, were on active follow-up, and had recent blood test results. Univariable and multivariable analyses were performed to identify significant associated factors for glycated hemoglobin (HbA1c) BP, and lipids. The response rate was 93.1% (700/752). The majority were females (52.8%), Malay (52.4%), and married (78.7%). DRD correlated with systolic BP (r= -0.16); depressive symptoms correlated with low-density lipoprotein cholesterol (r=0.12) and total cholesterol (r=0.13); medication adherence correlated with HbA1c (r= -0.14) and low-density lipoprotein cholesterol (r= -0.11); and HRQoL correlated with casual blood glucose (r= -0.11), high-density lipoprotein cholesterol (r= -0.13), and total cholesterol (r= -0.08). Multivariable analyses showed that HRQoL was significantly associated with casual blood glucose (adjusted B= -0.06, P=0.024); DRD was associated with systolic BP (adjusted B= -0.08, P=0.066); depressive symptoms were associated with low-density lipoprotein cholesterol (adjusted B=0.02, P=0.061), and medication adherence was associated with HbA1c (adjusted B= -0.11, P=0.082) and total cholesterol (adjusted B= -0.06, P=0.086). There were significant and distinctive associations of DRD, depressive symptoms, HRQoL, and medication adherence with glycemia, BP, and lipid biomarkers. Unexpected beneficial therapeutic effects of DRD on BP require further study. A multidisciplinary approach may be needed for risk management in adults with T2D at the primary care level. Dove Medical Press 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43885/1/Association%20of%20diabetes-related%20distress%2C%20depression%2C%20medication%20adherence%2C%20and%20health-related%20quality%20of%20life%20with%20glycated%20hemoglobin%2C%20blood%20pressure%2C%20and%20lipids%20in%20adult%20patients%20with%20type%202.pdf Chew, Boon How and Mohd Sidik, Sherina and Hassan, Noor Hasliza (2015) Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study. Therapeutics and Clinical Risk Management, 11. pp. 669-681. ISSN 1176-6336; ESSN: 1178-203X 10.2147/TCRM.S81623
institution UPM IR
collection UPM IR
language English
description This study examined the associations of diabetes-related distress (DRD), depressive symptoms, health-related quality of life (HRQoL), and medication adherence with glycemia, blood pressure (BP), and lipid biomarkers in adults with type 2 diabetes mellitus (T2D). This cross-sectional study was conducted in three Malaysian public health clinics in 2012–2013, recruited adult patients (aged ≥30 years) with T2D who had been diagnosed for more than one year, were on active follow-up, and had recent blood test results. Univariable and multivariable analyses were performed to identify significant associated factors for glycated hemoglobin (HbA1c) BP, and lipids. The response rate was 93.1% (700/752). The majority were females (52.8%), Malay (52.4%), and married (78.7%). DRD correlated with systolic BP (r= -0.16); depressive symptoms correlated with low-density lipoprotein cholesterol (r=0.12) and total cholesterol (r=0.13); medication adherence correlated with HbA1c (r= -0.14) and low-density lipoprotein cholesterol (r= -0.11); and HRQoL correlated with casual blood glucose (r= -0.11), high-density lipoprotein cholesterol (r= -0.13), and total cholesterol (r= -0.08). Multivariable analyses showed that HRQoL was significantly associated with casual blood glucose (adjusted B= -0.06, P=0.024); DRD was associated with systolic BP (adjusted B= -0.08, P=0.066); depressive symptoms were associated with low-density lipoprotein cholesterol (adjusted B=0.02, P=0.061), and medication adherence was associated with HbA1c (adjusted B= -0.11, P=0.082) and total cholesterol (adjusted B= -0.06, P=0.086). There were significant and distinctive associations of DRD, depressive symptoms, HRQoL, and medication adherence with glycemia, BP, and lipid biomarkers. Unexpected beneficial therapeutic effects of DRD on BP require further study. A multidisciplinary approach may be needed for risk management in adults with T2D at the primary care level.
format Article
author Chew, Boon How
Mohd Sidik, Sherina
Hassan, Noor Hasliza
spellingShingle Chew, Boon How
Mohd Sidik, Sherina
Hassan, Noor Hasliza
Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study
author_facet Chew, Boon How
Mohd Sidik, Sherina
Hassan, Noor Hasliza
author_sort Chew, Boon How
title Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study
title_short Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study
title_full Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study
title_fullStr Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study
title_full_unstemmed Associations of diabetes-related distress, depression, medication adherence and health-related quality of life with HbA1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study
title_sort associations of diabetes-related distress, depression, medication adherence and health-related quality of life with hba1c, blood pressure and lipids in adult patients with type 2 diabetes: a cross-sectional study
publisher Dove Medical Press
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/43885/1/Association%20of%20diabetes-related%20distress%2C%20depression%2C%20medication%20adherence%2C%20and%20health-related%20quality%20of%20life%20with%20glycated%20hemoglobin%2C%20blood%20pressure%2C%20and%20lipids%20in%20adult%20patients%20with%20type%202.pdf
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score 12.833586