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Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors

A series of forty-five 1,5-diphenylpenta-2,4-dien-1-one analogues were synthesized and evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 cells. Compounds 3h, 7a, 7d and 7e exhibited comparable or significantly higher activity than the standard, curcumin (IC50...

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Detaylı Bibliyografya
Asıl Yazarlar: Mohd Faudzi, S. M., Leong, S. W., Abas, F., Mohd Aluwi, M. F. F., Rullah, K., Lam, K. W., Ahmad, S., Tham, C. L., Shaari, K., Lajis, N. H.
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2015
Online Erişim:http://psasir.upm.edu.my/id/eprint/46477/1/Synthesis%2C%20biological%20evaluation%20and%20QSAR%20studies%20of%20diarylpentanoid%20analogues%20as%20potential%20nitric%20oxide%20inhibitors.pdf
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Internet

http://psasir.upm.edu.my/id/eprint/46477/1/Synthesis%2C%20biological%20evaluation%20and%20QSAR%20studies%20of%20diarylpentanoid%20analogues%20as%20potential%20nitric%20oxide%20inhibitors.pdf

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