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Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids

Since conjugated linoleic acid (CLA) has structural and physiological characteristics similar to peroxisome proliferators, it is hypothesized that CLA would upregulate peroxisome proliferator-activated receptor (PPAR) and liver fatty acid binding protein (LFABP) in the liver of broiler chicken. The...

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Auteurs principaux: Ramiah, Suriya Kumari, Yong Meng, Goh, Ebrahimi, Mahdi
Format: Article
Langue:English
Publié: Taylor & Francis Group 2015
Accès en ligne:http://psasir.upm.edu.my/id/eprint/46814/1/Upregulation%20of%20peroxisome%20proliferator-activated%20receptors%20and%20liver%20fatty%20acid%20binding%20protein%20in%20hepatic%20cells%20of%20broiler%20chicken%20supplemented%20with%20conjugated%20linoleic%20acids.pdf
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spelling oai:psasir.upm.edu.my:46814 http://psasir.upm.edu.my/id/eprint/46814/ Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids Ramiah, Suriya Kumari Yong Meng, Goh Ebrahimi, Mahdi Since conjugated linoleic acid (CLA) has structural and physiological characteristics similar to peroxisome proliferators, it is hypothesized that CLA would upregulate peroxisome proliferator-activated receptor (PPAR) and liver fatty acid binding protein (LFABP) in the liver of broiler chicken. The aim of the present study was to determine fatty acid composition of liver in CLA-fed broiler chickens and the genes associated with hepatic lipid metabolism. A total of 180-day-old broiler chicks were randomly assigned to two diets containing 0 and 2.5% CLA and fed for 6 weeks. Fatty acid (FA) composition of liver and PPAR α and γ and L-FABP were analyzed. It has been demonstrated that CLA was found in the liver of CLA-feed chicken compared to control group. Hepatic PPAR α and γ mRNA levels were upregulated 1.2 and 3-fold in CLA-fed chickens compared to chickens fed diet without CLA respectively. A similar response of upregulation was observed for L-FABP mRNA expression. Our data highlights the role of PPARs as a core regulator in the regulation of lipid metabolism in chicken liver. Taylor & Francis Group 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/46814/1/Upregulation%20of%20peroxisome%20proliferator-activated%20receptors%20and%20liver%20fatty%20acid%20binding%20protein%20in%20hepatic%20cells%20of%20broiler%20chicken%20supplemented%20with%20conjugated%20linoleic%20acids.pdf Ramiah, Suriya Kumari and Yong Meng, Goh and Ebrahimi, Mahdi (2015) Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids. Italian Journal of Animal Science , 14 (1). p. 1. ISSN 1594-4077; ESSN: 1828-051X 10.4081/ijas.2015.3846
institution UPM IR
collection UPM IR
language English
description Since conjugated linoleic acid (CLA) has structural and physiological characteristics similar to peroxisome proliferators, it is hypothesized that CLA would upregulate peroxisome proliferator-activated receptor (PPAR) and liver fatty acid binding protein (LFABP) in the liver of broiler chicken. The aim of the present study was to determine fatty acid composition of liver in CLA-fed broiler chickens and the genes associated with hepatic lipid metabolism. A total of 180-day-old broiler chicks were randomly assigned to two diets containing 0 and 2.5% CLA and fed for 6 weeks. Fatty acid (FA) composition of liver and PPAR α and γ and L-FABP were analyzed. It has been demonstrated that CLA was found in the liver of CLA-feed chicken compared to control group. Hepatic PPAR α and γ mRNA levels were upregulated 1.2 and 3-fold in CLA-fed chickens compared to chickens fed diet without CLA respectively. A similar response of upregulation was observed for L-FABP mRNA expression. Our data highlights the role of PPARs as a core regulator in the regulation of lipid metabolism in chicken liver.
format Article
author Ramiah, Suriya Kumari
Yong Meng, Goh
Ebrahimi, Mahdi
spellingShingle Ramiah, Suriya Kumari
Yong Meng, Goh
Ebrahimi, Mahdi
Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids
author_facet Ramiah, Suriya Kumari
Yong Meng, Goh
Ebrahimi, Mahdi
author_sort Ramiah, Suriya Kumari
title Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids
title_short Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids
title_full Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids
title_fullStr Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids
title_full_unstemmed Upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids
title_sort upregulation of peroxisome proliferator-activated receptors and liver fatty acid binding protein in hepatic cells of broiler chicken supplemented with conjugated linoleic acids
publisher Taylor & Francis Group
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/46814/1/Upregulation%20of%20peroxisome%20proliferator-activated%20receptors%20and%20liver%20fatty%20acid%20binding%20protein%20in%20hepatic%20cells%20of%20broiler%20chicken%20supplemented%20with%20conjugated%20linoleic%20acids.pdf
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score 13.4562235

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