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Role of microglia in embryonic neurogenesis

Microglia begin colonizing the developing brain as early as embryonic day 9, prior to the emergence of neurons and other glia. Their ontogeny is also distinct from other central nervous system cells, as they derive from yolk sac hematopoietic progenitors and not neural progenitors. In this review, w...

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Main Authors: Tong, Chih Kong, Vidyadaran, Sharmili
Format: Article
Language:English
Published: Sage Publications 2016
Online Access:http://psasir.upm.edu.my/id/eprint/52912/1/Role%20of%20microglia%20in%20embryonic%20neurogenesis.pdf
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spelling oai:psasir.upm.edu.my:52912 http://psasir.upm.edu.my/id/eprint/52912/ Role of microglia in embryonic neurogenesis Tong, Chih Kong Vidyadaran, Sharmili Microglia begin colonizing the developing brain as early as embryonic day 9, prior to the emergence of neurons and other glia. Their ontogeny is also distinct from other central nervous system cells, as they derive from yolk sac hematopoietic progenitors and not neural progenitors. In this review, we feature these unique characteristics of microglia and assess the spatiotemporal similarities between microglia colonization of the central nervous system and embryonic neurogenesis. We also infer to existing evidence for microglia function from embryonic through to postnatal neurodevelopment to postulate roles for microglia in neurogenesis. Sage Publications 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/52912/1/Role%20of%20microglia%20in%20embryonic%20neurogenesis.pdf Tong, Chih Kong and Vidyadaran, Sharmili (2016) Role of microglia in embryonic neurogenesis. Experimental Biology and Medicine, 241 (15). pp. 1669-1675. ISSN 1535-3702; ESSN: 1535-3699 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995495/ 10.1177/1535370216664430
institution UPM IR
collection UPM IR
language English
description Microglia begin colonizing the developing brain as early as embryonic day 9, prior to the emergence of neurons and other glia. Their ontogeny is also distinct from other central nervous system cells, as they derive from yolk sac hematopoietic progenitors and not neural progenitors. In this review, we feature these unique characteristics of microglia and assess the spatiotemporal similarities between microglia colonization of the central nervous system and embryonic neurogenesis. We also infer to existing evidence for microglia function from embryonic through to postnatal neurodevelopment to postulate roles for microglia in neurogenesis.
format Article
author Tong, Chih Kong
Vidyadaran, Sharmili
spellingShingle Tong, Chih Kong
Vidyadaran, Sharmili
Role of microglia in embryonic neurogenesis
author_facet Tong, Chih Kong
Vidyadaran, Sharmili
author_sort Tong, Chih Kong
title Role of microglia in embryonic neurogenesis
title_short Role of microglia in embryonic neurogenesis
title_full Role of microglia in embryonic neurogenesis
title_fullStr Role of microglia in embryonic neurogenesis
title_full_unstemmed Role of microglia in embryonic neurogenesis
title_sort role of microglia in embryonic neurogenesis
publisher Sage Publications
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/52912/1/Role%20of%20microglia%20in%20embryonic%20neurogenesis.pdf
_version_ 1819297297343709184
score 13.4562235

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