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Highly potent stem cells from full-term amniotic fluid: a realistic perspective

Amniotic fluid (AF) is now known to harbor highly potent stem cells, making it an excellent source for cell therapy. However, most of the stem cells isolated are from AF of mid-term pregnancies in which the collection procedure involves an invasive technique termed amniocentesis. This has limited th...

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Main Authors: A.Hamid, Adila, Joharry, Muhammad Khair, Hoo, Mun Fun, Hamzah, Siti Nurusaadah, Rejali, Zulida, Yazid, Mohd Nazri, Thilakavathy, Karuppiah, Nordin, Norshariza
Formáid: Article
Teanga:English
Foilsithe: Elsevier 2017
Rochtain Ar Líne:http://psasir.upm.edu.my/id/eprint/62034/1/Highly%20potent%20stem%20cells%20from%20full-term%20amniotic%20fluid.pdf
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id oai:psasir.upm.edu.my:62034
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spelling oai:psasir.upm.edu.my:62034 http://psasir.upm.edu.my/id/eprint/62034/ Highly potent stem cells from full-term amniotic fluid: a realistic perspective A.Hamid, Adila Joharry, Muhammad Khair Hoo, Mun Fun Hamzah, Siti Nurusaadah Rejali, Zulida Yazid, Mohd Nazri Thilakavathy, Karuppiah Nordin, Norshariza Amniotic fluid (AF) is now known to harbor highly potent stem cells, making it an excellent source for cell therapy. However, most of the stem cells isolated are from AF of mid-term pregnancies in which the collection procedure involves an invasive technique termed amniocentesis. This has limited the access in getting the fluid as the technique imposes certain level of risks to the mother as well as to the fetus. Alternatively, getting AF from full-term pregnancies or during deliveries would be a better resolution. Unfortunately, very few studies have isolated stem cells from AF at this stage of gestation, the fluid that is merely discarded during delivery. The question remains whether full-term AF harbors stem cells of similar potency as of the stem cells of mid-term AF. Here, we aim to review the prospect of having this type of stem cells by first looking at the origin and contents of AF particularly during different gestation period. We will then discuss the possibility that the AF, at full term, contains a population of highly potent stem cells. These stem cells are distinct from, and probably more potent than the AF mesenchymal stem cells (AF-MSCs) isolated from full-term AF. By comparing the studies on stem cells isolated from mid-term versus full-term AF from various species, we intend to address the prospect of having highly potent amniotic fluid stem cells from AF of full-term pregnancies in human and animals. Elsevier 2017-03 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62034/1/Highly%20potent%20stem%20cells%20from%20full-term%20amniotic%20fluid.pdf A.Hamid, Adila and Joharry, Muhammad Khair and Hoo, Mun Fun and Hamzah, Siti Nurusaadah and Rejali, Zulida and Yazid, Mohd Nazri and Thilakavathy, Karuppiah and Nordin, Norshariza (2017) Highly potent stem cells from full-term amniotic fluid: a realistic perspective. Reproductive Biology, 17 (1). pp. 9-18. ISSN 1642-431X; ESSN: 2300-732X https://www.sciencedirect.com/science/article/pii/S1642431X17300438?via%3Dihub 10.1016/j.repbio.2017.02.001
institution UPM IR
collection UPM IR
language English
description Amniotic fluid (AF) is now known to harbor highly potent stem cells, making it an excellent source for cell therapy. However, most of the stem cells isolated are from AF of mid-term pregnancies in which the collection procedure involves an invasive technique termed amniocentesis. This has limited the access in getting the fluid as the technique imposes certain level of risks to the mother as well as to the fetus. Alternatively, getting AF from full-term pregnancies or during deliveries would be a better resolution. Unfortunately, very few studies have isolated stem cells from AF at this stage of gestation, the fluid that is merely discarded during delivery. The question remains whether full-term AF harbors stem cells of similar potency as of the stem cells of mid-term AF. Here, we aim to review the prospect of having this type of stem cells by first looking at the origin and contents of AF particularly during different gestation period. We will then discuss the possibility that the AF, at full term, contains a population of highly potent stem cells. These stem cells are distinct from, and probably more potent than the AF mesenchymal stem cells (AF-MSCs) isolated from full-term AF. By comparing the studies on stem cells isolated from mid-term versus full-term AF from various species, we intend to address the prospect of having highly potent amniotic fluid stem cells from AF of full-term pregnancies in human and animals.
format Article
author A.Hamid, Adila
Joharry, Muhammad Khair
Hoo, Mun Fun
Hamzah, Siti Nurusaadah
Rejali, Zulida
Yazid, Mohd Nazri
Thilakavathy, Karuppiah
Nordin, Norshariza
spellingShingle A.Hamid, Adila
Joharry, Muhammad Khair
Hoo, Mun Fun
Hamzah, Siti Nurusaadah
Rejali, Zulida
Yazid, Mohd Nazri
Thilakavathy, Karuppiah
Nordin, Norshariza
Highly potent stem cells from full-term amniotic fluid: a realistic perspective
author_facet A.Hamid, Adila
Joharry, Muhammad Khair
Hoo, Mun Fun
Hamzah, Siti Nurusaadah
Rejali, Zulida
Yazid, Mohd Nazri
Thilakavathy, Karuppiah
Nordin, Norshariza
author_sort A.Hamid, Adila
title Highly potent stem cells from full-term amniotic fluid: a realistic perspective
title_short Highly potent stem cells from full-term amniotic fluid: a realistic perspective
title_full Highly potent stem cells from full-term amniotic fluid: a realistic perspective
title_fullStr Highly potent stem cells from full-term amniotic fluid: a realistic perspective
title_full_unstemmed Highly potent stem cells from full-term amniotic fluid: a realistic perspective
title_sort highly potent stem cells from full-term amniotic fluid: a realistic perspective
publisher Elsevier
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/62034/1/Highly%20potent%20stem%20cells%20from%20full-term%20amniotic%20fluid.pdf
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score 12.933938

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