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Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications

This paper describes the fabrication and characterization of bio-nanocomposite hydrogel beads based on Kappa-Carrageenan (κ-Carrageenan) and bio-synthesized silver nanoparticles (Ag-NPs). The silver nanoparticles were prepared in aqueous Citrullus colocynthis seed extract as both reducing and cappin...

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Main Authors: Azizi, Susan, Mohamad, Rosfarizan, Abdul Rahim, Raha, Mohammadinejad, Reza, Ariff, Arbakariya
Format: Article
Language:English
Published: Elsevier BV 2017
Online Access:http://psasir.upm.edu.my/id/eprint/62059/1/Hydrogel%20beads%20.pdf
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spelling oai:psasir.upm.edu.my:62059 http://psasir.upm.edu.my/id/eprint/62059/ Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications Azizi, Susan Mohamad, Rosfarizan Abdul Rahim, Raha Mohammadinejad, Reza Ariff, Arbakariya This paper describes the fabrication and characterization of bio-nanocomposite hydrogel beads based on Kappa-Carrageenan (κ-Carrageenan) and bio-synthesized silver nanoparticles (Ag-NPs). The silver nanoparticles were prepared in aqueous Citrullus colocynthis seed extract as both reducing and capping agent. Cross-linked κ-Carrageenan/Ag-NPs hydrogel beads were prepared using potassium chloride as the cross-linker. The hydrogel beads were characterized using XRD and FESEM. Moreover, swelling property of the hydrogel beads was investigated. The Ag release profile of the hydrogels was obtained by fitting the experimental data to power law equation. The direct visualization of the green synthesized Ag-NPs using TEM shows particle size in the range of 23 ± 2 nm. The bio-nanocomposite hydrogels showed lesser swelling behavior in comparison with pure κ-Carrageenan hydrogel. Regardless the slow Ag release, κ-Carrageenan/Ag-NPs presented good antibacterial activities against Staphylococcus aureus, Methicilin Resistant Staphylococcus aurous, Peseudomonas aeruginosa and Escherichia coli with maximum zones of inhibition 11 ± 2 mm. Cytotoxicity study showed that the bio-nanocomposite hydrogels with non-toxic effect of concentration below 1000 μg/mL have great pharmacological potential and a suitable level of safety for use in the biological systems. Elsevier BV 2017-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62059/1/Hydrogel%20beads%20.pdf Azizi, Susan and Mohamad, Rosfarizan and Abdul Rahim, Raha and Mohammadinejad, Reza and Ariff, Arbakariya (2017) Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications. International Journal of Biological Macromolecules, 104 (pt. A). 423 - 431. ISSN 0141-8130; ESSN: 1879-0003 https://www.sciencedirect.com/science/article/pii/S0141813016322164?via%3Dihub 10.1016/j.ijbiomac.2017.06.010
institution UPM IR
collection UPM IR
language English
description This paper describes the fabrication and characterization of bio-nanocomposite hydrogel beads based on Kappa-Carrageenan (κ-Carrageenan) and bio-synthesized silver nanoparticles (Ag-NPs). The silver nanoparticles were prepared in aqueous Citrullus colocynthis seed extract as both reducing and capping agent. Cross-linked κ-Carrageenan/Ag-NPs hydrogel beads were prepared using potassium chloride as the cross-linker. The hydrogel beads were characterized using XRD and FESEM. Moreover, swelling property of the hydrogel beads was investigated. The Ag release profile of the hydrogels was obtained by fitting the experimental data to power law equation. The direct visualization of the green synthesized Ag-NPs using TEM shows particle size in the range of 23 ± 2 nm. The bio-nanocomposite hydrogels showed lesser swelling behavior in comparison with pure κ-Carrageenan hydrogel. Regardless the slow Ag release, κ-Carrageenan/Ag-NPs presented good antibacterial activities against Staphylococcus aureus, Methicilin Resistant Staphylococcus aurous, Peseudomonas aeruginosa and Escherichia coli with maximum zones of inhibition 11 ± 2 mm. Cytotoxicity study showed that the bio-nanocomposite hydrogels with non-toxic effect of concentration below 1000 μg/mL have great pharmacological potential and a suitable level of safety for use in the biological systems.
format Article
author Azizi, Susan
Mohamad, Rosfarizan
Abdul Rahim, Raha
Mohammadinejad, Reza
Ariff, Arbakariya
spellingShingle Azizi, Susan
Mohamad, Rosfarizan
Abdul Rahim, Raha
Mohammadinejad, Reza
Ariff, Arbakariya
Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications
author_facet Azizi, Susan
Mohamad, Rosfarizan
Abdul Rahim, Raha
Mohammadinejad, Reza
Ariff, Arbakariya
author_sort Azizi, Susan
title Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications
title_short Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications
title_full Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications
title_fullStr Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications
title_full_unstemmed Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications
title_sort hydrogel beads bio-nanocomposite based on kappa-carrageenan and green synthesized silver nanoparticles for biomedical applications
publisher Elsevier BV
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/62059/1/Hydrogel%20beads%20.pdf
_version_ 1819298156523814912
score 13.4562235

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