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Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats

Calcium carbonate nanoparticles have shown promising potentials in the delivery of drugs and metabolites. There is however, a paucity of information on the safety of their intentional or accidental over exposures to biological systems and general health safety. To this end, this study aims at docume...

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Main Authors: Jaji, Alhaji Zubair, Zakaria, Zuki Abu Bakar, Mahmud, Rozi, Loqman, Mohamad Yusof, Mohamad Hezmee, Mohamad Noor, Abba, Yusuf, Isa, Tijani, Mahmood, Saffanah Khuder
Format: Article
Language:English
Published: Springer Verlag 2017
Online Access:http://psasir.upm.edu.my/id/eprint/63167/1/Safety%20assessments%20of%20subcutaneous%20doses%20of%20aragonite%20calcium%20carbonate%20nanocrystals%20in%20rats.pdf
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spelling oai:psasir.upm.edu.my:63167 http://psasir.upm.edu.my/id/eprint/63167/ Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats Jaji, Alhaji Zubair Zakaria, Zuki Abu Bakar Mahmud, Rozi Loqman, Mohamad Yusof Mohamad Hezmee, Mohamad Noor Abba, Yusuf Isa, Tijani Mahmood, Saffanah Khuder Calcium carbonate nanoparticles have shown promising potentials in the delivery of drugs and metabolites. There is however, a paucity of information on the safety of their intentional or accidental over exposures to biological systems and general health safety. To this end, this study aims at documenting information on the safety of subcutaneous doses of biogenic nanocrystals of aragonite polymorph of calcium carbonate derived from cockle shells (ANC) in Sprague-Dawley (SD) rats. ANC was synthesized using the top-down method, characterized using the transmission electron microscopy and field emission scanning electron microscope and its acute and repeated dose 28-day trial toxicities were evaluated in SD rats. The results showed that the homogenous 30 ± 5 nm-sized spherical pure aragonite nanocrystals were not associated with mortality in the rats. Severe clinical signs and gross and histopathological lesions, indicating organ toxicities, were recorded in the acute toxicity (29,500 mg/m2) group and the high dose (5900 mg/m2) group of the repeated dose 28-day trial. However, the medium- (590 mg/m2 body weight) and low (59 mg/m2)-dose groups showed moderate to mild lesions. The relatively mild lesions observed in the low toxicity dosage group marked the safety margin of ANC in SD rats. It was concluded from this study that the toxicity of CaCO3 was dependent on the particulate size (30 ± 5 nm) and concentration and the route of administration used. Springer Verlag 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63167/1/Safety%20assessments%20of%20subcutaneous%20doses%20of%20aragonite%20calcium%20carbonate%20nanocrystals%20in%20rats.pdf Jaji, Alhaji Zubair and Zakaria, Zuki Abu Bakar and Mahmud, Rozi and Loqman, Mohamad Yusof and Mohamad Hezmee, Mohamad Noor and Abba, Yusuf and Isa, Tijani and Mahmood, Saffanah Khuder (2017) Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats. Journal of Nanoparticle Research, 19 (175). pp. 1-18. ISSN 1388-0764; ESSN: 1572-896X 10.1007/s11051-017-3849-z
institution UPM IR
collection UPM IR
language English
description Calcium carbonate nanoparticles have shown promising potentials in the delivery of drugs and metabolites. There is however, a paucity of information on the safety of their intentional or accidental over exposures to biological systems and general health safety. To this end, this study aims at documenting information on the safety of subcutaneous doses of biogenic nanocrystals of aragonite polymorph of calcium carbonate derived from cockle shells (ANC) in Sprague-Dawley (SD) rats. ANC was synthesized using the top-down method, characterized using the transmission electron microscopy and field emission scanning electron microscope and its acute and repeated dose 28-day trial toxicities were evaluated in SD rats. The results showed that the homogenous 30 ± 5 nm-sized spherical pure aragonite nanocrystals were not associated with mortality in the rats. Severe clinical signs and gross and histopathological lesions, indicating organ toxicities, were recorded in the acute toxicity (29,500 mg/m2) group and the high dose (5900 mg/m2) group of the repeated dose 28-day trial. However, the medium- (590 mg/m2 body weight) and low (59 mg/m2)-dose groups showed moderate to mild lesions. The relatively mild lesions observed in the low toxicity dosage group marked the safety margin of ANC in SD rats. It was concluded from this study that the toxicity of CaCO3 was dependent on the particulate size (30 ± 5 nm) and concentration and the route of administration used.
format Article
author Jaji, Alhaji Zubair
Zakaria, Zuki Abu Bakar
Mahmud, Rozi
Loqman, Mohamad Yusof
Mohamad Hezmee, Mohamad Noor
Abba, Yusuf
Isa, Tijani
Mahmood, Saffanah Khuder
spellingShingle Jaji, Alhaji Zubair
Zakaria, Zuki Abu Bakar
Mahmud, Rozi
Loqman, Mohamad Yusof
Mohamad Hezmee, Mohamad Noor
Abba, Yusuf
Isa, Tijani
Mahmood, Saffanah Khuder
Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats
author_facet Jaji, Alhaji Zubair
Zakaria, Zuki Abu Bakar
Mahmud, Rozi
Loqman, Mohamad Yusof
Mohamad Hezmee, Mohamad Noor
Abba, Yusuf
Isa, Tijani
Mahmood, Saffanah Khuder
author_sort Jaji, Alhaji Zubair
title Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats
title_short Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats
title_full Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats
title_fullStr Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats
title_full_unstemmed Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats
title_sort safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats
publisher Springer Verlag
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/63167/1/Safety%20assessments%20of%20subcutaneous%20doses%20of%20aragonite%20calcium%20carbonate%20nanocrystals%20in%20rats.pdf
_version_ 1782756518401146880
score 12.933938

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