Personeel: Cytomegalovirus replication steps and the actions of antiviral drugs

Cytomegalovirus replication steps and the actions of antiviral drugs

Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipul...

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Hoofdauteurs:	Abdullah, Ashwaq Ahmed, Balakrishnan, Krishnan Nair, Bala, Jamilu Abubakar, Abdullah, Faez Firdaus Jesse, Allaudin, Zeenatul Nazariah, Abdullah, Rasedee, Noordin, Mohamed Mustapha, Mohd Lila, Mohd Azmi
Formaat:	Artikel
Taal:	English
Gepubliceerd in:	Bentham Science Publishers 2018
Online toegang:	http://psasir.upm.edu.my/id/eprint/72163/1/Cytomegalovirus%20replication%20steps%20and%20the%20actions%20of%20antiviral%20drugs.pdf
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id	oai:psasir.upm.edu.my:72163
record_format	eprints
spelling	oai:psasir.upm.edu.my:72163 http://psasir.upm.edu.my/id/eprint/72163/ Cytomegalovirus replication steps and the actions of antiviral drugs Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipulate how the virus replicates and minimize its pathogenicity. The five antiviral drugs approved by the Food and Drug Administration (FDA) have shown adverse reactions and the antiviral drug resistance were reported. Hence, this warrants the need for urgent development of a novel antiviral drug. Detailed understanding of the virus replication steps and how cellular signals interact with these steps will be key for pharmacological developments of for anti HCMV drugs. This review summarized all the drugs that target the virus proteins and cell signals that mediate CMV replication. Bentham Science Publishers 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72163/1/Cytomegalovirus%20replication%20steps%20and%20the%20actions%20of%20antiviral%20drugs.pdf Abdullah, Ashwaq Ahmed and Balakrishnan, Krishnan Nair and Bala, Jamilu Abubakar and Abdullah, Faez Firdaus Jesse and Allaudin, Zeenatul Nazariah and Abdullah, Rasedee and Noordin, Mohamed Mustapha and Mohd Lila, Mohd Azmi (2018) Cytomegalovirus replication steps and the actions of antiviral drugs. Anti-Infective Agents, 16 (2). 80 - 95. ISSN 2211-3525; ESSN: 2211-3533 http://www.eurekaselect.com/163113/article 10.2174/2211352516666180619155021
institution	UPM IR
collection	UPM IR
language	English
description	Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipulate how the virus replicates and minimize its pathogenicity. The five antiviral drugs approved by the Food and Drug Administration (FDA) have shown adverse reactions and the antiviral drug resistance were reported. Hence, this warrants the need for urgent development of a novel antiviral drug. Detailed understanding of the virus replication steps and how cellular signals interact with these steps will be key for pharmacological developments of for anti HCMV drugs. This review summarized all the drugs that target the virus proteins and cell signals that mediate CMV replication.
format	Article
author	Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi
spellingShingle	Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi Cytomegalovirus replication steps and the actions of antiviral drugs
author_facet	Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi
author_sort	Abdullah, Ashwaq Ahmed
title	Cytomegalovirus replication steps and the actions of antiviral drugs
title_short	Cytomegalovirus replication steps and the actions of antiviral drugs
title_full	Cytomegalovirus replication steps and the actions of antiviral drugs
title_fullStr	Cytomegalovirus replication steps and the actions of antiviral drugs
title_full_unstemmed	Cytomegalovirus replication steps and the actions of antiviral drugs
title_sort	cytomegalovirus replication steps and the actions of antiviral drugs
publisher	Bentham Science Publishers
publishDate	2018
url	http://psasir.upm.edu.my/id/eprint/72163/1/Cytomegalovirus%20replication%20steps%20and%20the%20actions%20of%20antiviral%20drugs.pdf
_version_	1819299016770322432
score	13.4562235

Cytomegalovirus replication steps and the actions of antiviral drugs

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