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Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences

To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung hist...

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Main Authors: Syed Saudi, Siti Noor Sakinah, Kumaran, Sharmilah Kumari, Munisvaradass, Rusheni, Mok, Pooi Ling, Chee, Hui Yee, Seenichamy, Arivudainambi, Vijayaraman, Kiruthiga P., Higuchi, Akon, Rajan, Mariappan, Seenivasan, K. Nataraja, Marlina, Arulselvan, Palanisamy, Benelli, Giovanni, Subbiah, Suresh Kumar
Format: Article
Language:English
Published: Taylor and Francis 2018
Online Access:http://psasir.upm.edu.my/id/eprint/72600/1/Repeated%20infections%20of%20dengue%20.pdf
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spelling oai:psasir.upm.edu.my:72600 http://psasir.upm.edu.my/id/eprint/72600/ Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences Syed Saudi, Siti Noor Sakinah Kumaran, Sharmilah Kumari Munisvaradass, Rusheni Mok, Pooi Ling Chee, Hui Yee Seenichamy, Arivudainambi Vijayaraman, Kiruthiga P. Higuchi, Akon Rajan, Mariappan Seenivasan, K. Nataraja Marlina Arulselvan, Palanisamy Benelli, Giovanni Subbiah, Suresh Kumar To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung histopathology of BALB/c mice infected twice by DENV-2 showed the presence of hemorrhage, plasma leakage and presence of hemosiderin-laden macrophages (HLMs). Notably, in the lung of BALB/c mice infected four times by DENV-2, we observed thickening and disruption of the alveolar septum, inflammatory cell infiltration, plasma leakage and increased cellularity. Megakaryocyte releasing platelets were also found into the lung alveolus. Overall, our findings showed severe histopathological damage in lungs repeatedly infected by DENV-2, allowing us to argue that they can be linked to pulmonary complication. Result also showed that the number of infections with similar total DENV-2 titer led to different histopathological changes. Taylor and Francis 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72600/1/Repeated%20infections%20of%20dengue%20.pdf Syed Saudi, Siti Noor Sakinah and Kumaran, Sharmilah Kumari and Munisvaradass, Rusheni and Mok, Pooi Ling and Chee, Hui Yee and Seenichamy, Arivudainambi and Vijayaraman, Kiruthiga P. and Higuchi, Akon and Rajan, Mariappan and Seenivasan, K. Nataraja and Marlina and Arulselvan, Palanisamy and Benelli, Giovanni and Subbiah, Suresh Kumar (2018) Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences. Pathogens and Global Health, 112 (5). 259 - 267. ISSN 2047-7724; ESSN: 2047-7732 https://www.tandfonline.com/doi/abs/10.1080/20477724.2018.1492765 10.1080/20477724.2018.1492765
institution UPM IR
collection UPM IR
language English
description To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung histopathology of BALB/c mice infected twice by DENV-2 showed the presence of hemorrhage, plasma leakage and presence of hemosiderin-laden macrophages (HLMs). Notably, in the lung of BALB/c mice infected four times by DENV-2, we observed thickening and disruption of the alveolar septum, inflammatory cell infiltration, plasma leakage and increased cellularity. Megakaryocyte releasing platelets were also found into the lung alveolus. Overall, our findings showed severe histopathological damage in lungs repeatedly infected by DENV-2, allowing us to argue that they can be linked to pulmonary complication. Result also showed that the number of infections with similar total DENV-2 titer led to different histopathological changes.
format Article
author Syed Saudi, Siti Noor Sakinah
Kumaran, Sharmilah Kumari
Munisvaradass, Rusheni
Mok, Pooi Ling
Chee, Hui Yee
Seenichamy, Arivudainambi
Vijayaraman, Kiruthiga P.
Higuchi, Akon
Rajan, Mariappan
Seenivasan, K. Nataraja
Marlina
Arulselvan, Palanisamy
Benelli, Giovanni
Subbiah, Suresh Kumar
spellingShingle Syed Saudi, Siti Noor Sakinah
Kumaran, Sharmilah Kumari
Munisvaradass, Rusheni
Mok, Pooi Ling
Chee, Hui Yee
Seenichamy, Arivudainambi
Vijayaraman, Kiruthiga P.
Higuchi, Akon
Rajan, Mariappan
Seenivasan, K. Nataraja
Marlina
Arulselvan, Palanisamy
Benelli, Giovanni
Subbiah, Suresh Kumar
Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences
author_facet Syed Saudi, Siti Noor Sakinah
Kumaran, Sharmilah Kumari
Munisvaradass, Rusheni
Mok, Pooi Ling
Chee, Hui Yee
Seenichamy, Arivudainambi
Vijayaraman, Kiruthiga P.
Higuchi, Akon
Rajan, Mariappan
Seenivasan, K. Nataraja
Marlina
Arulselvan, Palanisamy
Benelli, Giovanni
Subbiah, Suresh Kumar
author_sort Syed Saudi, Siti Noor Sakinah
title Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences
title_short Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences
title_full Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences
title_fullStr Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences
title_full_unstemmed Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences
title_sort repeated infections of dengue (serotype denv-2) in lung cells of balb/c mice lead to severe histopathological consequences
publisher Taylor and Francis
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/72600/1/Repeated%20infections%20of%20dengue%20.pdf
_version_ 1782758147389128704
score 12.935284

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