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Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells

Objective: To identify the bioactive extracts from Alternanthera sessilis and investigate its cytotoxicity potential against colon cancer cells, HT-29. Methods: This study examined the effects of three parts (aerial, leaf, stem) of whole plant on HT-29 colon cancer cell lines. Three different extrac...

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Hoofdauteurs: Mohd Esa, Norhaizan, Muniandy, Katyakyini, Sivapragasam, Gothai, Subbiah, Suresh Kumar, Arulselvan, Palanisamy
Formaat: Artikel
Taal:English
Gepubliceerd in: Wolters Kluwer Medknow Publications 2018
Online toegang:http://psasir.upm.edu.my/id/eprint/73151/1/CANCER.pdf
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spelling oai:psasir.upm.edu.my:73151 http://psasir.upm.edu.my/id/eprint/73151/ Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells Mohd Esa, Norhaizan Muniandy, Katyakyini Sivapragasam, Gothai Subbiah, Suresh Kumar Arulselvan, Palanisamy Objective: To identify the bioactive extracts from Alternanthera sessilis and investigate its cytotoxicity potential against colon cancer cells, HT-29. Methods: This study examined the effects of three parts (aerial, leaf, stem) of whole plant on HT-29 colon cancer cell lines. Three different extracts from the plant parts were prepared by maceration technique using 80% ethanol. The anticancer activities were determined using MTT, clonogenic, cell motility and AOPI assay. The chemical composition profiling was analyzed by GC-MS. Results: Among three plant part extracts, leaf extract greatly suppressed the growth of colon cancer cells in time and dosage-dependent manner, followed by aerial and stem. The cytotoxicity results were rationalized with clonogenic, cell motility and AO/PI assay, where extract showed the most active activity compared to aerial and stem extracts. GC-MS analysis of leaf extract showed there were various recognized anti-cancer, anti-oxidant and anti-inflammatory compounds. Conclusions: Amid the screened extracts, the leaf extract exhibits the credible cytotoxic, anti-proliferative and apoptotic activity and hence, our findings call for additional research to conclude the active compounds and their mechanisms determining the apoptotic activity. Wolters Kluwer Medknow Publications 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73151/1/CANCER.pdf Mohd Esa, Norhaizan and Muniandy, Katyakyini and Sivapragasam, Gothai and Subbiah, Suresh Kumar and Arulselvan, Palanisamy (2018) Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells. Asian Pacific Journal of Tropical Biomedicine, 8 (8). 394 - 402. ISSN 2221-1691; ESSN: 2588-9222 https://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=8;spage=394;epage=402;aulast=Gothai 10.4103/2221-1691.239427
institution UPM IR
collection UPM IR
language English
description Objective: To identify the bioactive extracts from Alternanthera sessilis and investigate its cytotoxicity potential against colon cancer cells, HT-29. Methods: This study examined the effects of three parts (aerial, leaf, stem) of whole plant on HT-29 colon cancer cell lines. Three different extracts from the plant parts were prepared by maceration technique using 80% ethanol. The anticancer activities were determined using MTT, clonogenic, cell motility and AOPI assay. The chemical composition profiling was analyzed by GC-MS. Results: Among three plant part extracts, leaf extract greatly suppressed the growth of colon cancer cells in time and dosage-dependent manner, followed by aerial and stem. The cytotoxicity results were rationalized with clonogenic, cell motility and AO/PI assay, where extract showed the most active activity compared to aerial and stem extracts. GC-MS analysis of leaf extract showed there were various recognized anti-cancer, anti-oxidant and anti-inflammatory compounds. Conclusions: Amid the screened extracts, the leaf extract exhibits the credible cytotoxic, anti-proliferative and apoptotic activity and hence, our findings call for additional research to conclude the active compounds and their mechanisms determining the apoptotic activity.
format Article
author Mohd Esa, Norhaizan
Muniandy, Katyakyini
Sivapragasam, Gothai
Subbiah, Suresh Kumar
Arulselvan, Palanisamy
spellingShingle Mohd Esa, Norhaizan
Muniandy, Katyakyini
Sivapragasam, Gothai
Subbiah, Suresh Kumar
Arulselvan, Palanisamy
Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells
author_facet Mohd Esa, Norhaizan
Muniandy, Katyakyini
Sivapragasam, Gothai
Subbiah, Suresh Kumar
Arulselvan, Palanisamy
author_sort Mohd Esa, Norhaizan
title Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells
title_short Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells
title_full Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells
title_fullStr Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells
title_full_unstemmed Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells
title_sort anticancer potential of alternanthera sessilis extract on ht-29 human colon cancer cells
publisher Wolters Kluwer Medknow Publications
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73151/1/CANCER.pdf
_version_ 1819299083034034176
score 13.4562235

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