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Antioxidant and oxidative stress: a mutual interplay in age-related diseases

Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant spe...

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Hauptverfasser: Mohd Esa, Norhaizan, Liew, Winnie Pui Pui, Tan, Bee Ling, Rahman, Heshu Sulaiman
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media 2018
Online Zugang:http://psasir.upm.edu.my/id/eprint/73167/1/OXIDATIVE.pdf
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spelling oai:psasir.upm.edu.my:73167 http://psasir.upm.edu.my/id/eprint/73167/ Antioxidant and oxidative stress: a mutual interplay in age-related diseases Mohd Esa, Norhaizan Liew, Winnie Pui Pui Tan, Bee Ling Rahman, Heshu Sulaiman Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity. Frontiers Media 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73167/1/OXIDATIVE.pdf Mohd Esa, Norhaizan and Liew, Winnie Pui Pui and Tan, Bee Ling and Rahman, Heshu Sulaiman (2018) Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Frontiers in Pharmacology, 9. art. no. 1162. pp. 1-28. ISSN 1663-9812 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204759/pdf/fphar-09-01162.pdf 10.3389/fphar.2018.01162
institution UPM IR
collection UPM IR
language English
description Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
format Article
author Mohd Esa, Norhaizan
Liew, Winnie Pui Pui
Tan, Bee Ling
Rahman, Heshu Sulaiman
spellingShingle Mohd Esa, Norhaizan
Liew, Winnie Pui Pui
Tan, Bee Ling
Rahman, Heshu Sulaiman
Antioxidant and oxidative stress: a mutual interplay in age-related diseases
author_facet Mohd Esa, Norhaizan
Liew, Winnie Pui Pui
Tan, Bee Ling
Rahman, Heshu Sulaiman
author_sort Mohd Esa, Norhaizan
title Antioxidant and oxidative stress: a mutual interplay in age-related diseases
title_short Antioxidant and oxidative stress: a mutual interplay in age-related diseases
title_full Antioxidant and oxidative stress: a mutual interplay in age-related diseases
title_fullStr Antioxidant and oxidative stress: a mutual interplay in age-related diseases
title_full_unstemmed Antioxidant and oxidative stress: a mutual interplay in age-related diseases
title_sort antioxidant and oxidative stress: a mutual interplay in age-related diseases
publisher Frontiers Media
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73167/1/OXIDATIVE.pdf
_version_ 1819299083887575040
score 13.4562235

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