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Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection

Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine...

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Main Authors: Md Isa, Nur Mahiza, Basripuzi, N. Hayyan, Salisi, Mohd Shahrom, Busin, Valentina, Cairns, Callum, Jenvey, Caitlin, Stear, Michael J.
Formáid: Article
Teanga:English
Foilsithe: Elsevier 2018
Rochtain Ar Líne:http://psasir.upm.edu.my/id/eprint/73295/1/GOAT.pdf
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id oai:psasir.upm.edu.my:73295
record_format eprints
spelling oai:psasir.upm.edu.my:73295 http://psasir.upm.edu.my/id/eprint/73295/ Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection Md Isa, Nur Mahiza Basripuzi, N. Hayyan Salisi, Mohd Shahrom Busin, Valentina Cairns, Callum Jenvey, Caitlin Stear, Michael J. Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep. Elsevier 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73295/1/GOAT.pdf Md Isa, Nur Mahiza and Basripuzi, N. Hayyan and Salisi, Mohd Shahrom and Busin, Valentina and Cairns, Callum and Jenvey, Caitlin and Stear, Michael J. (2018) Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection. Veterinary Parasitology, 264. 18 - 25. ISSN 0304-4017; ESSN: 1873-2550 https://www.sciencedirect.com/science/article/abs/pii/S0304401718303510#! 10.1016/j.vetpar.2018.10.014
institution UPM IR
collection UPM IR
language English
description Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep.
format Article
author Md Isa, Nur Mahiza
Basripuzi, N. Hayyan
Salisi, Mohd Shahrom
Busin, Valentina
Cairns, Callum
Jenvey, Caitlin
Stear, Michael J.
spellingShingle Md Isa, Nur Mahiza
Basripuzi, N. Hayyan
Salisi, Mohd Shahrom
Busin, Valentina
Cairns, Callum
Jenvey, Caitlin
Stear, Michael J.
Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection
author_facet Md Isa, Nur Mahiza
Basripuzi, N. Hayyan
Salisi, Mohd Shahrom
Busin, Valentina
Cairns, Callum
Jenvey, Caitlin
Stear, Michael J.
author_sort Md Isa, Nur Mahiza
title Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection
title_short Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection
title_full Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection
title_fullStr Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection
title_full_unstemmed Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection
title_sort boer goats appear to lack a functional iga and eosinophil response against natural nematode infection
publisher Elsevier
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73295/1/GOAT.pdf
_version_ 1819299088215048192
score 13.4562235

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