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Recent updates on treatment of ocular microbial infections by stem cell therapy: a review

Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may re...

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Main Authors: Teh, Seoh Wei, Mok, Pooi Ling, Abd Rashid, Munirah, Bastion, Mae-Lynn Catherine, Ibrahim, Normala, Higuchi, Akon, Murugan, Kadarkarai, Mariappan, Rajan, Subbiah, Suresh Kumar
Format: Article
Language:English
Published: MDPI 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73720/1/Recent%20updates%20on%20treatment%20of%20ocular%20microbial%20infections%20by%20stem%20cell%20therapy%20a%20review.pdf
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spelling oai:psasir.upm.edu.my:73720 http://psasir.upm.edu.my/id/eprint/73720/ Recent updates on treatment of ocular microbial infections by stem cell therapy: a review Teh, Seoh Wei Mok, Pooi Ling Abd Rashid, Munirah Bastion, Mae-Lynn Catherine Ibrahim, Normala Higuchi, Akon Murugan, Kadarkarai Mariappan, Rajan Subbiah, Suresh Kumar Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area. In cases where there is concurrent inflammation, once infection is controlled, anti-inflammatory agents are indicated to reduce ocular damage from inflammation which ensues. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a vast variety of cell types following proper differentiation protocol. Stem cell therapy shows promise in reducing inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to modulate immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges. We also provide recent updates of the advances in stem cells studies on sepsis therapy as a suggestion of optimum treatment regime for ocular microbial infections. MDPI 2018 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/73720/1/Recent%20updates%20on%20treatment%20of%20ocular%20microbial%20infections%20by%20stem%20cell%20therapy%20a%20review.pdf Teh, Seoh Wei and Mok, Pooi Ling and Abd Rashid, Munirah and Bastion, Mae-Lynn Catherine and Ibrahim, Normala and Higuchi, Akon and Murugan, Kadarkarai and Mariappan, Rajan and Subbiah, Suresh Kumar (2018) Recent updates on treatment of ocular microbial infections by stem cell therapy: a review. International Journal of Molecular Sciences, 19 (2). pp. 1-26. ISSN 1661-6596; ESSN: 1422-0067 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855780/ 10.3390/ijms19020558
institution UPM IR
collection UPM IR
language English
description Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area. In cases where there is concurrent inflammation, once infection is controlled, anti-inflammatory agents are indicated to reduce ocular damage from inflammation which ensues. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a vast variety of cell types following proper differentiation protocol. Stem cell therapy shows promise in reducing inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to modulate immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges. We also provide recent updates of the advances in stem cells studies on sepsis therapy as a suggestion of optimum treatment regime for ocular microbial infections.
format Article
author Teh, Seoh Wei
Mok, Pooi Ling
Abd Rashid, Munirah
Bastion, Mae-Lynn Catherine
Ibrahim, Normala
Higuchi, Akon
Murugan, Kadarkarai
Mariappan, Rajan
Subbiah, Suresh Kumar
spellingShingle Teh, Seoh Wei
Mok, Pooi Ling
Abd Rashid, Munirah
Bastion, Mae-Lynn Catherine
Ibrahim, Normala
Higuchi, Akon
Murugan, Kadarkarai
Mariappan, Rajan
Subbiah, Suresh Kumar
Recent updates on treatment of ocular microbial infections by stem cell therapy: a review
author_facet Teh, Seoh Wei
Mok, Pooi Ling
Abd Rashid, Munirah
Bastion, Mae-Lynn Catherine
Ibrahim, Normala
Higuchi, Akon
Murugan, Kadarkarai
Mariappan, Rajan
Subbiah, Suresh Kumar
author_sort Teh, Seoh Wei
title Recent updates on treatment of ocular microbial infections by stem cell therapy: a review
title_short Recent updates on treatment of ocular microbial infections by stem cell therapy: a review
title_full Recent updates on treatment of ocular microbial infections by stem cell therapy: a review
title_fullStr Recent updates on treatment of ocular microbial infections by stem cell therapy: a review
title_full_unstemmed Recent updates on treatment of ocular microbial infections by stem cell therapy: a review
title_sort recent updates on treatment of ocular microbial infections by stem cell therapy: a review
publisher MDPI
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73720/1/Recent%20updates%20on%20treatment%20of%20ocular%20microbial%20infections%20by%20stem%20cell%20therapy%20a%20review.pdf
_version_ 1782758265003704320
score 12.933938

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