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The 'checkmate' for iron between human host and invading bacteria: chess game analogy

Iron is an essential nutrient for all living organisms with critical roles in many biological processes. The mammalian host maintains the iron requirements by dietary intake, while the invading pathogenic bacteria compete with the host to obtain those absorbed irons. In order to limit the iron uptak...

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Main Authors: Kalidasan, V., Joseph, Narcisse, Subbiah, Suresh Kumar, Awang Hamat, Rukman, Neela, Vasantha Kumari
Format: Article
Language:English
Published: Springer Verlag 2018
Online Access:http://psasir.upm.edu.my/id/eprint/74104/1/The%20%27checkmate%27%20for%20iron%20between%20human%20host%20and%20invading%20bacteria%20chess%20game%20analogy.pdf
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spelling oai:psasir.upm.edu.my:74104 http://psasir.upm.edu.my/id/eprint/74104/ The 'checkmate' for iron between human host and invading bacteria: chess game analogy Kalidasan, V. Joseph, Narcisse Subbiah, Suresh Kumar Awang Hamat, Rukman Neela, Vasantha Kumari Iron is an essential nutrient for all living organisms with critical roles in many biological processes. The mammalian host maintains the iron requirements by dietary intake, while the invading pathogenic bacteria compete with the host to obtain those absorbed irons. In order to limit the iron uptake by the bacteria, the human host employs numerous iron binding proteins and withholding defense mechanisms that capture iron from the microbial invaders. To counteract, the bacteria cope with the iron limitation imposed by the host by expressing various iron acquisition systems, allowing them to achieve effective iron homeostasis. The armamentarium used by the human host and invading bacteria, leads to the dilemma of who wins the ultimate war for iron. Springer Verlag 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74104/1/The%20%27checkmate%27%20for%20iron%20between%20human%20host%20and%20invading%20bacteria%20chess%20game%20analogy.pdf Kalidasan, V. and Joseph, Narcisse and Subbiah, Suresh Kumar and Awang Hamat, Rukman and Neela, Vasantha Kumari (2018) The 'checkmate' for iron between human host and invading bacteria: chess game analogy. Indian Journal of Microbiology, 58 (3). 257 - 267. ISSN 0046-8991; ESSN: 0973-7715 10.1007/s12088-018-0740-2
institution UPM IR
collection UPM IR
language English
description Iron is an essential nutrient for all living organisms with critical roles in many biological processes. The mammalian host maintains the iron requirements by dietary intake, while the invading pathogenic bacteria compete with the host to obtain those absorbed irons. In order to limit the iron uptake by the bacteria, the human host employs numerous iron binding proteins and withholding defense mechanisms that capture iron from the microbial invaders. To counteract, the bacteria cope with the iron limitation imposed by the host by expressing various iron acquisition systems, allowing them to achieve effective iron homeostasis. The armamentarium used by the human host and invading bacteria, leads to the dilemma of who wins the ultimate war for iron.
format Article
author Kalidasan, V.
Joseph, Narcisse
Subbiah, Suresh Kumar
Awang Hamat, Rukman
Neela, Vasantha Kumari
spellingShingle Kalidasan, V.
Joseph, Narcisse
Subbiah, Suresh Kumar
Awang Hamat, Rukman
Neela, Vasantha Kumari
The 'checkmate' for iron between human host and invading bacteria: chess game analogy
author_facet Kalidasan, V.
Joseph, Narcisse
Subbiah, Suresh Kumar
Awang Hamat, Rukman
Neela, Vasantha Kumari
author_sort Kalidasan, V.
title The 'checkmate' for iron between human host and invading bacteria: chess game analogy
title_short The 'checkmate' for iron between human host and invading bacteria: chess game analogy
title_full The 'checkmate' for iron between human host and invading bacteria: chess game analogy
title_fullStr The 'checkmate' for iron between human host and invading bacteria: chess game analogy
title_full_unstemmed The 'checkmate' for iron between human host and invading bacteria: chess game analogy
title_sort 'checkmate' for iron between human host and invading bacteria: chess game analogy
publisher Springer Verlag
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/74104/1/The%20%27checkmate%27%20for%20iron%20between%20human%20host%20and%20invading%20bacteria%20chess%20game%20analogy.pdf
_version_ 1819299149360660480
score 13.4562235

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