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Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate

The newly discovered Trio high-fecundity allele produces multiple ovulations in cattle. This study evaluated (1) size and growth rates of follicles in Trio carriers during a synchronized follicular wave, induced by follicle aspiration; (2) follicle-stimulating hormone (FSH) patterns associated with...

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Autores Principales: Guerra, Alvaro Garcia, Kamalludin, Mamat Hamidi, Kirkpatrick, Brian W., Wiltbank, Milo C.
Formato: Artículo
Lenguaje:English
Publicado: Society for the Study of Reproduction 2018
Acceso en línea:http://psasir.upm.edu.my/id/eprint/74344/1/Trio%20a%20novel%20bovine%20high-fecundity%20allele%20II.%20Hormonal%20profile%20and%20follicular%20dynamics%20underlying%20the%20high%20ovulation%20rate.pdf
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spelling oai:psasir.upm.edu.my:74344 http://psasir.upm.edu.my/id/eprint/74344/ Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate Guerra, Alvaro Garcia Kamalludin, Mamat Hamidi Kirkpatrick, Brian W. Wiltbank, Milo C. The newly discovered Trio high-fecundity allele produces multiple ovulations in cattle. This study evaluated (1) size and growth rates of follicles in Trio carriers during a synchronized follicular wave, induced by follicle aspiration; (2) follicle-stimulating hormone (FSH) patterns associated with the follicular wave; (3) size of corpora lutea (CL) and circulating progesterone; and (4) intrafollicular estradiol concentrations prior to normal deviation. Trio carriers had mean dominant follicles that were significantly smaller in diameter and volume than noncarriers. Onset of diameter deviation occurred at ∼3 days after the last follicle aspiration in both genotypes despite Trio carriers having much smaller individual follicles. Follicles of Trio carriers grew at a slower rate than noncarrier follicles (∼65% in mm/day or ∼30% in mm3/day) resulting in much smaller individual dominant follicles (∼25% volume). However, total dominant follicle volume, calculated as the sum of all dominant follicles in each animal, was similar in carriers and noncarriers of Trio throughout the entire follicular wave. Circulating FSH was greater in Trio carriers during the 24 h encompassing deviation. Trio carriers had significantly more ovulations than noncarriers, and individual CL volume was smaller, although total luteal tissue volume and circulating P4 were not different. Thus, increased ovulation rate in Trio carriers relates to smaller individual follicles (one-third the volume) near the time of deviation due to slower follicle growth rate, although time of deviation is similar, with increased circulating FSH near deviation leading to selection of multiple dominant follicles in Trio carriers with similar total follicle volume. Society for the Study of Reproduction 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74344/1/Trio%20a%20novel%20bovine%20high-fecundity%20allele%20II.%20Hormonal%20profile%20and%20follicular%20dynamics%20underlying%20the%20high%20ovulation%20rate.pdf Guerra, Alvaro Garcia and Kamalludin, Mamat Hamidi and Kirkpatrick, Brian W. and Wiltbank, Milo C. (2018) Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate. Biology of Reproduction, 98 (3). 335 - 349. ISSN 0006-3363; ESSN: 1529-7268 10.1093/biolre/iox156
institution UPM IR
collection UPM IR
language English
description The newly discovered Trio high-fecundity allele produces multiple ovulations in cattle. This study evaluated (1) size and growth rates of follicles in Trio carriers during a synchronized follicular wave, induced by follicle aspiration; (2) follicle-stimulating hormone (FSH) patterns associated with the follicular wave; (3) size of corpora lutea (CL) and circulating progesterone; and (4) intrafollicular estradiol concentrations prior to normal deviation. Trio carriers had mean dominant follicles that were significantly smaller in diameter and volume than noncarriers. Onset of diameter deviation occurred at ∼3 days after the last follicle aspiration in both genotypes despite Trio carriers having much smaller individual follicles. Follicles of Trio carriers grew at a slower rate than noncarrier follicles (∼65% in mm/day or ∼30% in mm3/day) resulting in much smaller individual dominant follicles (∼25% volume). However, total dominant follicle volume, calculated as the sum of all dominant follicles in each animal, was similar in carriers and noncarriers of Trio throughout the entire follicular wave. Circulating FSH was greater in Trio carriers during the 24 h encompassing deviation. Trio carriers had significantly more ovulations than noncarriers, and individual CL volume was smaller, although total luteal tissue volume and circulating P4 were not different. Thus, increased ovulation rate in Trio carriers relates to smaller individual follicles (one-third the volume) near the time of deviation due to slower follicle growth rate, although time of deviation is similar, with increased circulating FSH near deviation leading to selection of multiple dominant follicles in Trio carriers with similar total follicle volume.
format Article
author Guerra, Alvaro Garcia
Kamalludin, Mamat Hamidi
Kirkpatrick, Brian W.
Wiltbank, Milo C.
spellingShingle Guerra, Alvaro Garcia
Kamalludin, Mamat Hamidi
Kirkpatrick, Brian W.
Wiltbank, Milo C.
Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate
author_facet Guerra, Alvaro Garcia
Kamalludin, Mamat Hamidi
Kirkpatrick, Brian W.
Wiltbank, Milo C.
author_sort Guerra, Alvaro Garcia
title Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate
title_short Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate
title_full Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate
title_fullStr Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate
title_full_unstemmed Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate
title_sort trio a novel bovine high-fecundity allele: ii. hormonal profile and follicular dynamics underlying the high ovulation rate
publisher Society for the Study of Reproduction
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/74344/1/Trio%20a%20novel%20bovine%20high-fecundity%20allele%20II.%20Hormonal%20profile%20and%20follicular%20dynamics%20underlying%20the%20high%20ovulation%20rate.pdf
_version_ 1819299165159555072
score 13.4562235

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