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Diagnostic methods for feline coronavirus: a review

Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is ne...

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Main Authors: Sharif, Saeed, Arshad, Siti Suri, Bejo, Mohd Hair, Omar, Abdul Rahman, Allaudin, Zeenathul Nazariah, Alazawy, Amer
Format: Article
Language:English
Published: SAGE-Hindawi Access to Research 2010
Online Access:http://psasir.upm.edu.my/id/eprint/7722/1/809480.pdf
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spelling oai:psasir.upm.edu.my:7722 http://psasir.upm.edu.my/id/eprint/7722/ Diagnostic methods for feline coronavirus: a review Sharif, Saeed Arshad, Siti Suri Bejo, Mohd Hair Omar, Abdul Rahman Allaudin, Zeenathul Nazariah Alazawy, Amer Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is neither an effective vaccine, nor a curative treatment for FIP, a diagnostic protocol for FCoV would greatly assist in the management and control of the virus. Clinical findings in FIP are non-specific and not helpful in making a differential diagnosis. Haematological and biochemical abnormalities in FIP cases are also non-specific. The currently available serological tests have low specificity and sensitivity for detection of active infection and cross-react with FCoV strains of low pathogenicity, the feline enteric coronaviruses (FECV). Reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect FCoV and is rapid and sensitive, but results must be interpreted in the context of clinical findings. At present, a definitive diagnosis of FIP can be established only by histopathological examination of biopsies. This paper describes and compares diagnostic methods for FCoVs and includes a brief account of the virus biology, epidemiology, and pathogenesis. SAGE-Hindawi Access to Research 2010 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/7722/1/809480.pdf Sharif, Saeed and Arshad, Siti Suri and Bejo, Mohd Hair and Omar, Abdul Rahman and Allaudin, Zeenathul Nazariah and Alazawy, Amer (2010) Diagnostic methods for feline coronavirus: a review. Veterinary Medicine International, 2010. art. no. 809480. pp. 1-7. ISSN 2090-8113; ESSN: 2042-0048 https://www.hindawi.com/journals/vmi/2010/809480/abs/ 10.4061/2010/809480
institution UPM IR
collection UPM IR
language English
description Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is neither an effective vaccine, nor a curative treatment for FIP, a diagnostic protocol for FCoV would greatly assist in the management and control of the virus. Clinical findings in FIP are non-specific and not helpful in making a differential diagnosis. Haematological and biochemical abnormalities in FIP cases are also non-specific. The currently available serological tests have low specificity and sensitivity for detection of active infection and cross-react with FCoV strains of low pathogenicity, the feline enteric coronaviruses (FECV). Reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect FCoV and is rapid and sensitive, but results must be interpreted in the context of clinical findings. At present, a definitive diagnosis of FIP can be established only by histopathological examination of biopsies. This paper describes and compares diagnostic methods for FCoVs and includes a brief account of the virus biology, epidemiology, and pathogenesis.
format Article
author Sharif, Saeed
Arshad, Siti Suri
Bejo, Mohd Hair
Omar, Abdul Rahman
Allaudin, Zeenathul Nazariah
Alazawy, Amer
spellingShingle Sharif, Saeed
Arshad, Siti Suri
Bejo, Mohd Hair
Omar, Abdul Rahman
Allaudin, Zeenathul Nazariah
Alazawy, Amer
Diagnostic methods for feline coronavirus: a review
author_facet Sharif, Saeed
Arshad, Siti Suri
Bejo, Mohd Hair
Omar, Abdul Rahman
Allaudin, Zeenathul Nazariah
Alazawy, Amer
author_sort Sharif, Saeed
title Diagnostic methods for feline coronavirus: a review
title_short Diagnostic methods for feline coronavirus: a review
title_full Diagnostic methods for feline coronavirus: a review
title_fullStr Diagnostic methods for feline coronavirus: a review
title_full_unstemmed Diagnostic methods for feline coronavirus: a review
title_sort diagnostic methods for feline coronavirus: a review
publisher SAGE-Hindawi Access to Research
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/7722/1/809480.pdf
_version_ 1819293202263310336
score 13.4562235

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