Knjižničarski pogled: Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep

Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep

The effect of phenobarbitone against signal grass (Brachiaria decumbens) toxicity was studied in 26 male crossbred sheep. Grazing on signal grass significantly decreased the concentration of cytochrome P-450 and the activity of drug metabolizing enzymes, viz. aminopyrine-N-demethylase, aniline-4-hyd...

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Main Authors:	Ab. Hamid, Hasiah, H. A., ElSheikh, Abdullah, Abdul Salam, Hussain, Mohd Khairi, Rajion, Mohamed Ali
Format:	Article
Jezik:	English English English
Izdano:	Elsevier Science 2000
Online dostop:	http://psasir.upm.edu.my/id/eprint/7861/1/Effect%20of%20Phenobarbitone%20Treatment%20Against%20Signal%20Grass.pdf http://psasir.upm.edu.my/id/eprint/7861/7/1-s2.0-S1090023300904982-main.pdf
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id	oai:psasir.upm.edu.my:7861
record_format	eprints
spelling	oai:psasir.upm.edu.my:7861 http://psasir.upm.edu.my/id/eprint/7861/ Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep Ab. Hamid, Hasiah H. A., ElSheikh Abdullah, Abdul Salam Hussain, Mohd Khairi Rajion, Mohamed Ali The effect of phenobarbitone against signal grass (Brachiaria decumbens) toxicity was studied in 26 male crossbred sheep. Grazing on signal grass significantly decreased the concentration of cytochrome P-450 and the activity of drug metabolizing enzymes, viz. aminopyrine-N-demethylase, aniline-4-hydroxylase, UDP- glucuronyltransferase and glutathione-S-transferase in liver and kidneys of affected sheep. Oral administration of phenobarbitone (30 mg/kg body weight) for five consecutive days before grazing on B. decumbens pasture, and thereafter, for three consecutive days every two weeks, resulted in significant increases in hepatic and renal activities of drug-metabolizing enzymes. The induction of drug metabolizing activity in sheep grazing on signal grass group was found to be lower than in animals given phenobarbitone alone. Induction by phenobarbitone provided a degree of protection against the toxic effects of B. decumbens as indicated by the delay in the appearance of signs of toxicity. Furthermore, these were much milder compared to those in the sheep not treated with phenobarbitone. The present study suggests that phenobarbitone-type cytochrome P-450 isoenzyme-induction may increase resistance against signal grass (B. decumbens) toxicity in sheep. Elsevier Science 2000-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/7861/1/Effect%20of%20Phenobarbitone%20Treatment%20Against%20Signal%20Grass.pdf text en http://psasir.upm.edu.my/id/eprint/7861/7/1-s2.0-S1090023300904982-main.pdf Ab. Hamid, Hasiah and H. A., ElSheikh and Abdullah, Abdul Salam and Hussain, Mohd Khairi and Rajion, Mohamed Ali (2000) Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep. The Veterinary Journal, 160 (3). pp. 267-272. ISSN 1090-0233 http://dx.doi.org/10.1053/tvjl.2000.0498 10.1053/tvjl.2000.0498 English
institution	UPM IR
collection	UPM IR
language	English English English
description	The effect of phenobarbitone against signal grass (Brachiaria decumbens) toxicity was studied in 26 male crossbred sheep. Grazing on signal grass significantly decreased the concentration of cytochrome P-450 and the activity of drug metabolizing enzymes, viz. aminopyrine-N-demethylase, aniline-4-hydroxylase, UDP- glucuronyltransferase and glutathione-S-transferase in liver and kidneys of affected sheep. Oral administration of phenobarbitone (30 mg/kg body weight) for five consecutive days before grazing on B. decumbens pasture, and thereafter, for three consecutive days every two weeks, resulted in significant increases in hepatic and renal activities of drug-metabolizing enzymes. The induction of drug metabolizing activity in sheep grazing on signal grass group was found to be lower than in animals given phenobarbitone alone. Induction by phenobarbitone provided a degree of protection against the toxic effects of B. decumbens as indicated by the delay in the appearance of signs of toxicity. Furthermore, these were much milder compared to those in the sheep not treated with phenobarbitone. The present study suggests that phenobarbitone-type cytochrome P-450 isoenzyme-induction may increase resistance against signal grass (B. decumbens) toxicity in sheep.
format	Article
author	Ab. Hamid, Hasiah H. A., ElSheikh Abdullah, Abdul Salam Hussain, Mohd Khairi Rajion, Mohamed Ali
spellingShingle	Ab. Hamid, Hasiah H. A., ElSheikh Abdullah, Abdul Salam Hussain, Mohd Khairi Rajion, Mohamed Ali Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep
author_facet	Ab. Hamid, Hasiah H. A., ElSheikh Abdullah, Abdul Salam Hussain, Mohd Khairi Rajion, Mohamed Ali
author_sort	Ab. Hamid, Hasiah
title	Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep
title_short	Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep
title_full	Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep
title_fullStr	Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep
title_full_unstemmed	Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep
title_sort	effect of phenobarbitone treatment against signal grass (brachiaria decumbens) toxicity in sheep
publisher	Elsevier Science
publishDate	2000
url	http://psasir.upm.edu.my/id/eprint/7861/1/Effect%20of%20Phenobarbitone%20Treatment%20Against%20Signal%20Grass.pdf http://psasir.upm.edu.my/id/eprint/7861/7/1-s2.0-S1090023300904982-main.pdf
_version_	1819293215431327744
score	13.4562235

Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep

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