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The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression

Cancer has become the global health, social, and economic burden that direly needs a revolutionized novel treatment for a broad spectrum of tumors. Among the innovative and promising therapeutic modalities, the use of mesenchymal stem cells (MSCs) as a tool for delivering an antitumorigenic activity...

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Main Authors: Ramasamy, Rajesh, Sarmadi, Vahid Hosseinpour
מחברים אחרים: Thomas, Jince
פורמט: Book Section
שפה:English
יצא לאור: Apple Academic Press 2019
גישה מקוונת:http://psasir.upm.edu.my/id/eprint/78994/1/The%20multiple%20facets%20of%20mesenchymal%20stem%20cells%20in%20modulating%20tumour%20cells%E2%80%99%20proliferation%20and%20progression.pdf
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spelling oai:psasir.upm.edu.my:78994 http://psasir.upm.edu.my/id/eprint/78994/ The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression Ramasamy, Rajesh Sarmadi, Vahid Hosseinpour Cancer has become the global health, social, and economic burden that direly needs a revolutionized novel treatment for a broad spectrum of tumors. Among the innovative and promising therapeutic modalities, the use of mesenchymal stem cells (MSCs) as a tool for delivering an antitumorigenic activity via its inherent antiproliferative capability or transportation of proteins or genes that suppress tumor has created a new way to circumvent cancers. MSCs are one of the most studied adult stem cells in the field of regenerative medicine, gene therapy, and immunomodulation due to its unique biological characteristics. Upon an in vivo administration, MSCs are able to migrate and home to the tumor site and exert either stimulatory or inhibitory effects on tumor cell growth, invasion, and metastasis via regulating angiogenesis, altering immune surveillance, modifying signaling pathways, and regulating apoptosis. Nonetheless, the mechanisms involved in the reported inhibition or stimulation are still elusive. Therefore, a better understanding of the biological consequences of MSCs–tumor interaction, prior to a successful MSCs based therapy, should be warranted. In this chapter, a number of previous findings associated with mutual interplays between MSCs and tumor cells are summarized and highlighted. Apple Academic Press Thomas, Jince Thomas, Sabu Kalarikkal, Nandakumar Jose, Jiya 2019 Book Section PeerReviewed text en http://psasir.upm.edu.my/id/eprint/78994/1/The%20multiple%20facets%20of%20mesenchymal%20stem%20cells%20in%20modulating%20tumour%20cells%E2%80%99%20proliferation%20and%20progression.pdf Ramasamy, Rajesh and Sarmadi, Vahid Hosseinpour (2019) The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression. In: Nanoparticles in Polymer Systems for Biomedical Applications. Apple Academic Press, Boca Raton, Florida, 245 - 261. ISBN 9781351047883 https://www.taylorfrancis.com/chapters/edit/10.1201/9781351047883-10/multiple-facets-mesenchymal-stem-cells-modulating-tumor-cells-proliferation-progression-rajesh-ramasamy-vahid-hosseinpour-sarmadi 10.1201/9781351047883-10
institution UPM IR
collection UPM IR
language English
description Cancer has become the global health, social, and economic burden that direly needs a revolutionized novel treatment for a broad spectrum of tumors. Among the innovative and promising therapeutic modalities, the use of mesenchymal stem cells (MSCs) as a tool for delivering an antitumorigenic activity via its inherent antiproliferative capability or transportation of proteins or genes that suppress tumor has created a new way to circumvent cancers. MSCs are one of the most studied adult stem cells in the field of regenerative medicine, gene therapy, and immunomodulation due to its unique biological characteristics. Upon an in vivo administration, MSCs are able to migrate and home to the tumor site and exert either stimulatory or inhibitory effects on tumor cell growth, invasion, and metastasis via regulating angiogenesis, altering immune surveillance, modifying signaling pathways, and regulating apoptosis. Nonetheless, the mechanisms involved in the reported inhibition or stimulation are still elusive. Therefore, a better understanding of the biological consequences of MSCs–tumor interaction, prior to a successful MSCs based therapy, should be warranted. In this chapter, a number of previous findings associated with mutual interplays between MSCs and tumor cells are summarized and highlighted.
author2 Thomas, Jince
author_facet Thomas, Jince
Ramasamy, Rajesh
Sarmadi, Vahid Hosseinpour
format Book Section
author Ramasamy, Rajesh
Sarmadi, Vahid Hosseinpour
spellingShingle Ramasamy, Rajesh
Sarmadi, Vahid Hosseinpour
The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression
author_sort Ramasamy, Rajesh
title The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression
title_short The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression
title_full The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression
title_fullStr The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression
title_full_unstemmed The multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression
title_sort multiple facets of mesenchymal stem cells in modulating tumour cells’ proliferation and progression
publisher Apple Academic Press
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/78994/1/The%20multiple%20facets%20of%20mesenchymal%20stem%20cells%20in%20modulating%20tumour%20cells%E2%80%99%20proliferation%20and%20progression.pdf
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score 13.4562235

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