Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration
Obesity has been on the rise in Malaysia in recent years. The intestinal microbiota potentially influences this condition via its effects on whole-body metabolism and weight management. This study aimed to investigate the effects of probiotic drink ingestion on the intestinal microbiota in 42 school...
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oai:psasir.upm.edu.my:80026 http://psasir.upm.edu.my/id/eprint/80026/ Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration Joseph, Narcisse Vasodavan, Kalidasan Saipudin, Nurul Ain Mohd Yusof, Barakatun Nisak Kumar, Suresh Amin Nordin, Syafinaz Obesity has been on the rise in Malaysia in recent years. The intestinal microbiota potentially influences this condition via its effects on whole-body metabolism and weight management. This study aimed to investigate the effects of probiotic drink ingestion on the intestinal microbiota in 42 school children. The subjects were classified as normal weight and overweight and were further divided into intervention and control groups. Faecal samples were obtained from the children, followed by qPCR analysis of the gut microbiota and high-performance liquid chromatography analysis of short-chain fatty acids (SCFAs). Results suggest that consumption of probiotic drinks is associated with significant alterations in the gut microbiota composition of Lactobacillus spp. and Bifidobacterium spp. (p = 0.002). The total SCFA and propionic acid contents increased significantly from baseline in normal weight children. Significant differences were observed for total SCFAs (p = 0.005) and propionic acid among overweight children (p = 0.001). Consumption of Lactobacillus casei Shirota (LcS)-fermented probiotic drinks potentially altered the gut microbiota composition of Lactobacillus spp. and Bifidobacterium spp. in children, concordant with changes in SCFAs; however, further investigation of this phenomenon is warranted. Elsevier BV 2019 Article PeerReviewed Joseph, Narcisse and Vasodavan, Kalidasan and Saipudin, Nurul Ain and Mohd Yusof, Barakatun Nisak and Kumar, Suresh and Amin Nordin, Syafinaz (2019) Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration. Journal of Functional Foods, 57. pp. 103-111. ISSN 1756-4646; ESSN: 2214-9414 https://www.sciencedirect.com/science/article/pii/S1756464619301689 10.1016/j.jff.2019.03.042 |
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Obesity has been on the rise in Malaysia in recent years. The intestinal microbiota potentially influences this condition via its effects on whole-body metabolism and weight management. This study aimed to investigate the effects of probiotic drink ingestion on the intestinal microbiota in 42 school children. The subjects were classified as normal weight and overweight and were further divided into intervention and control groups. Faecal samples were obtained from the children, followed by qPCR analysis of the gut microbiota and high-performance liquid chromatography analysis of short-chain fatty acids (SCFAs). Results suggest that consumption of probiotic drinks is associated with significant alterations in the gut microbiota composition of Lactobacillus spp. and Bifidobacterium spp. (p = 0.002). The total SCFA and propionic acid contents increased significantly from baseline in normal weight children. Significant differences were observed for total SCFAs (p = 0.005) and propionic acid among overweight children (p = 0.001). Consumption of Lactobacillus casei Shirota (LcS)-fermented probiotic drinks potentially altered the gut microbiota composition of Lactobacillus spp. and Bifidobacterium spp. in children, concordant with changes in SCFAs; however, further investigation of this phenomenon is warranted. |
| format |
Article |
| author |
Joseph, Narcisse Vasodavan, Kalidasan Saipudin, Nurul Ain Mohd Yusof, Barakatun Nisak Kumar, Suresh Amin Nordin, Syafinaz |
| spellingShingle |
Joseph, Narcisse Vasodavan, Kalidasan Saipudin, Nurul Ain Mohd Yusof, Barakatun Nisak Kumar, Suresh Amin Nordin, Syafinaz Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration |
| author_facet |
Joseph, Narcisse Vasodavan, Kalidasan Saipudin, Nurul Ain Mohd Yusof, Barakatun Nisak Kumar, Suresh Amin Nordin, Syafinaz |
| author_sort |
Joseph, Narcisse |
| title |
Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration |
| title_short |
Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration |
| title_full |
Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration |
| title_fullStr |
Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration |
| title_full_unstemmed |
Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration |
| title_sort |
gut microbiota and short-chain fatty acids (scfas) profiles of normal and overweight school children in selangor after probiotics administration |
| publisher |
Elsevier BV |
| publishDate |
2019 |
| _version_ |
1819299639961059328 |
| score |
13.4562235 |