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Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo

The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effect...

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Main Authors: Zainal, Zaida, Abdul Rahim, Afiqah, Radhakrishnan, Ammu Kutty, Sui, Kiat Chang, Khaza'ai, Huzwah
Format: Article
Language:English
Published: Nature Publishing Group 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80325/1/Investigation%20of%20the%20curative%20effects%20of%20palm%20vitamin%20E%20tocotrienols%20on%20autoimmune%20arthritis%20disease%20in%20vivo.pdf
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spelling oai:psasir.upm.edu.my:80325 http://psasir.upm.edu.my/id/eprint/80325/ Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo Zainal, Zaida Abdul Rahim, Afiqah Radhakrishnan, Ammu Kutty Sui, Kiat Chang Khaza'ai, Huzwah The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF. Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA. Nature Publishing Group 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80325/1/Investigation%20of%20the%20curative%20effects%20of%20palm%20vitamin%20E%20tocotrienols%20on%20autoimmune%20arthritis%20disease%20in%20vivo.pdf Zainal, Zaida and Abdul Rahim, Afiqah and Radhakrishnan, Ammu Kutty and Sui, Kiat Chang and Khaza'ai, Huzwah (2019) Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo. Scientific Reports, 9 (16793). pp. 1-11. ISSN 2045-2322 https://www.researchgate.net/publication/337248515_Investigation_of_the_curative_effects_of_palm_vitamin_E_tocotrienols_on_autoimmune_arthritis_disease_in_vivo 10.1038/s41598-019-53424-7
institution UPM IR
collection UPM IR
language English
description The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF. Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA.
format Article
author Zainal, Zaida
Abdul Rahim, Afiqah
Radhakrishnan, Ammu Kutty
Sui, Kiat Chang
Khaza'ai, Huzwah
spellingShingle Zainal, Zaida
Abdul Rahim, Afiqah
Radhakrishnan, Ammu Kutty
Sui, Kiat Chang
Khaza'ai, Huzwah
Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
author_facet Zainal, Zaida
Abdul Rahim, Afiqah
Radhakrishnan, Ammu Kutty
Sui, Kiat Chang
Khaza'ai, Huzwah
author_sort Zainal, Zaida
title Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_short Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_full Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_fullStr Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_full_unstemmed Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_sort investigation of the curative effects of palm vitamin e tocotrienols on autoimmune arthritis disease in vivo
publisher Nature Publishing Group
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80325/1/Investigation%20of%20the%20curative%20effects%20of%20palm%20vitamin%20E%20tocotrienols%20on%20autoimmune%20arthritis%20disease%20in%20vivo.pdf
_version_ 1819299666371543040
score 13.4562235

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