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Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents

Andrographolide (AGP), a naturally occurring bioactive compound, has been investigated as a lead compound in cancer drug development. Its multidimensional therapeutic effects have raised interest among medicinal chemists, which has led to extensive structural modification of the compound, resulting...

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Main Authors: Soo, Hon Liong, Quah, Shun Ying, Sulaiman, Ibrahim, Sagineedu, Sreenivasa Rao, Lim, Chee Woei, Stanslas, Johnson
Format: Article
Language:English
Published: Elsevier 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80553/1/ANDRO.pdf
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spelling oai:psasir.upm.edu.my:80553 http://psasir.upm.edu.my/id/eprint/80553/ Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents Soo, Hon Liong Quah, Shun Ying Sulaiman, Ibrahim Sagineedu, Sreenivasa Rao Lim, Chee Woei Stanslas, Johnson Andrographolide (AGP), a naturally occurring bioactive compound, has been investigated as a lead compound in cancer drug development. Its multidimensional therapeutic effects have raised interest among medicinal chemists, which has led to extensive structural modification of the compound, resulting in analogues with improved pharmacological and pharmaceutical properties. Nevertheless, the analogues with the improved properties need to be rigorously studied to identify drug-like lead compounds. We scrutinised articles published from 2012 to 2018, to objectively provide opinions on the mechanisms of action of AGP and its analogues, as well as their potential as viable anticancer drugs. Preclinical and clinical data, along with the extensive medicinal chemistry efforts, indicate the compounds are potential anticancer agents with specific value in treating recalcitrant cancers such as pancreatic and lung cancers. Elsevier 2019-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80553/1/ANDRO.pdf Soo, Hon Liong and Quah, Shun Ying and Sulaiman, Ibrahim and Sagineedu, Sreenivasa Rao and Lim, Chee Woei and Stanslas, Johnson (2019) Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents. Drug Discovery Today, 24 (9). pp. 1890-1898. ISSN 1359-6446; ESSN: 1878-5832 https://www.sciencedirect.com/science/article/pii/S1359644618302216 10.1016/j.drudis.2019.05.017
institution UPM IR
collection UPM IR
language English
description Andrographolide (AGP), a naturally occurring bioactive compound, has been investigated as a lead compound in cancer drug development. Its multidimensional therapeutic effects have raised interest among medicinal chemists, which has led to extensive structural modification of the compound, resulting in analogues with improved pharmacological and pharmaceutical properties. Nevertheless, the analogues with the improved properties need to be rigorously studied to identify drug-like lead compounds. We scrutinised articles published from 2012 to 2018, to objectively provide opinions on the mechanisms of action of AGP and its analogues, as well as their potential as viable anticancer drugs. Preclinical and clinical data, along with the extensive medicinal chemistry efforts, indicate the compounds are potential anticancer agents with specific value in treating recalcitrant cancers such as pancreatic and lung cancers.
format Article
author Soo, Hon Liong
Quah, Shun Ying
Sulaiman, Ibrahim
Sagineedu, Sreenivasa Rao
Lim, Chee Woei
Stanslas, Johnson
spellingShingle Soo, Hon Liong
Quah, Shun Ying
Sulaiman, Ibrahim
Sagineedu, Sreenivasa Rao
Lim, Chee Woei
Stanslas, Johnson
Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
author_facet Soo, Hon Liong
Quah, Shun Ying
Sulaiman, Ibrahim
Sagineedu, Sreenivasa Rao
Lim, Chee Woei
Stanslas, Johnson
author_sort Soo, Hon Liong
title Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
title_short Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
title_full Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
title_fullStr Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
title_full_unstemmed Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
title_sort advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
publisher Elsevier
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80553/1/ANDRO.pdf
_version_ 1819299675821309952
score 13.4562235

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