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Comparison of pathogenesis of Berghei infection in mouse and rats models

Background: The cytokine cascade in the immunopathogenesis of malaria infection had been widely studied. However, their specific association with survival and severe infection remained obscure. Methods: The study investigated the cytokine profiles and histopathological features of malaria in the sev...

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Main Authors: Basir, Rusliza, Hassan, Haniza, Zakaria, Zainul Amiruddin, Nordin, Norshariza, Chin, Voon Kin, Lee, Tze Yan, Chong, Wing Chui
Format: Article
Language:English
Published: University of Malaya 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80783/1/MALARIA.pdf
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spelling oai:psasir.upm.edu.my:80783 http://psasir.upm.edu.my/id/eprint/80783/ Comparison of pathogenesis of Berghei infection in mouse and rats models Basir, Rusliza Hassan, Haniza Zakaria, Zainul Amiruddin Nordin, Norshariza Chin, Voon Kin Lee, Tze Yan Chong, Wing Chui Background: The cytokine cascade in the immunopathogenesis of malaria infection had been widely studied. However, their specific association with survival and severe infection remained obscure. Methods: The study investigated the cytokine profiles and histopathological features of malaria in the severe infection and survival models by using male ICR mice and male Sprague Dawley rats respectively. Results: The severe model, the infected ICR mice, exhibited a high parasitemia with 100% mortality after peak parasitemia at day 5 post-infection. The survival model, the infected Sprague Dawley rats, showed mild parasitemia with full recovery by day 14 of infection. Both severe and survival models showed similar histopathological severity during peak parasitemia. The severe model produced highly elevated levels of proinflammatory cytokines, TNF-α and IL-1α, and low levels of the anti-inflammatory cytokine, IL-4; while the survival model showed low levels of TNF-α and IL-1α with high levels of IL-4. Conclusion: There were differences in the pathogenesis of the severe and survival models of malaria infection. These could be a basis for immunotherapy of malaria in the future. University of Malaya 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80783/1/MALARIA.pdf Basir, Rusliza and Hassan, Haniza and Zakaria, Zainul Amiruddin and Nordin, Norshariza and Chin, Voon Kin and Lee, Tze Yan and Chong, Wing Chui (2019) Comparison of pathogenesis of Berghei infection in mouse and rats models. Journal of Health and Translational Medicine (JUMMEC), 22 (2). pp. 4-12. ISSN 1823-7339; ESSN: 2289-392X https://jummec.um.edu.my/article/view/16835/10562
institution UPM IR
collection UPM IR
language English
description Background: The cytokine cascade in the immunopathogenesis of malaria infection had been widely studied. However, their specific association with survival and severe infection remained obscure. Methods: The study investigated the cytokine profiles and histopathological features of malaria in the severe infection and survival models by using male ICR mice and male Sprague Dawley rats respectively. Results: The severe model, the infected ICR mice, exhibited a high parasitemia with 100% mortality after peak parasitemia at day 5 post-infection. The survival model, the infected Sprague Dawley rats, showed mild parasitemia with full recovery by day 14 of infection. Both severe and survival models showed similar histopathological severity during peak parasitemia. The severe model produced highly elevated levels of proinflammatory cytokines, TNF-α and IL-1α, and low levels of the anti-inflammatory cytokine, IL-4; while the survival model showed low levels of TNF-α and IL-1α with high levels of IL-4. Conclusion: There were differences in the pathogenesis of the severe and survival models of malaria infection. These could be a basis for immunotherapy of malaria in the future.
format Article
author Basir, Rusliza
Hassan, Haniza
Zakaria, Zainul Amiruddin
Nordin, Norshariza
Chin, Voon Kin
Lee, Tze Yan
Chong, Wing Chui
spellingShingle Basir, Rusliza
Hassan, Haniza
Zakaria, Zainul Amiruddin
Nordin, Norshariza
Chin, Voon Kin
Lee, Tze Yan
Chong, Wing Chui
Comparison of pathogenesis of Berghei infection in mouse and rats models
author_facet Basir, Rusliza
Hassan, Haniza
Zakaria, Zainul Amiruddin
Nordin, Norshariza
Chin, Voon Kin
Lee, Tze Yan
Chong, Wing Chui
author_sort Basir, Rusliza
title Comparison of pathogenesis of Berghei infection in mouse and rats models
title_short Comparison of pathogenesis of Berghei infection in mouse and rats models
title_full Comparison of pathogenesis of Berghei infection in mouse and rats models
title_fullStr Comparison of pathogenesis of Berghei infection in mouse and rats models
title_full_unstemmed Comparison of pathogenesis of Berghei infection in mouse and rats models
title_sort comparison of pathogenesis of berghei infection in mouse and rats models
publisher University of Malaya
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80783/1/MALARIA.pdf
_version_ 1819299688650637312
score 13.4562235

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