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Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus

Alzheimer's disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ)...

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Main Authors: Musa Chiroma, Samaila, Baharuldin, Mohamad Taufik Hidayat, Mat Taib, Che Norma, Amom, Zulkhairi, Jagadeesan, Saravanan, Adenan, Mohd Ilham, Mahdi, Onesimus, Mohd Moklas, Mohamad Aris
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80875/1/ASIATA.pdf
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spelling oai:psasir.upm.edu.my:80875 http://psasir.upm.edu.my/id/eprint/80875/ Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus Musa Chiroma, Samaila Baharuldin, Mohamad Taufik Hidayat Mat Taib, Che Norma Amom, Zulkhairi Jagadeesan, Saravanan Adenan, Mohd Ilham Mahdi, Onesimus Mohd Moklas, Mohamad Aris Alzheimer's disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. Centella asiatica (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions. This study aimed to evaluate the effectiveness of CA in preventing d-galactose/aluminium chloride (d-gal/AlCl3) induced AD-like pathologies and the underlying mechanisms of action were further investigated for the first time. Results showed that co-administration of CA to d-gal/AlCl3 induced AD-like rat models significantly increased the levels of protein phosphatase 2 (PP2A) and decreased the levels of glycogen synthase kinase-3 beta (GSK-3β). It was further observed that, CA increased the expression of mRNA of Bcl-2, while there was minimal effect on the expression of caspase 3 mRNA. The results also showed that, CA prevented morphological aberrations in the connus ammonis 3 (CA 3) sub-region of the rat's hippocampus. The results clearly demonstrated for the first time that CA could alleviate d-gal/AlCl3 induced AD-like pathologies in rats via inhibition of hyperphosphorylated tau (P-tau) bio-synthetic proteins, anti-apoptosis and maintenance of cytoarchitecture. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80875/1/ASIATA.pdf Musa Chiroma, Samaila and Baharuldin, Mohamad Taufik Hidayat and Mat Taib, Che Norma and Amom, Zulkhairi and Jagadeesan, Saravanan and Adenan, Mohd Ilham and Mahdi, Onesimus and Mohd Moklas, Mohamad Aris (2019) Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus. International Journal of Molecular Sciences, 20 (8). pp. 1-14. ISSN 1661-6596; ESSN: 1422-0067 https://pubmed.ncbi.nlm.nih.gov/31014012/ 10.3390/ijms20081871
institution UPM IR
collection UPM IR
language English
description Alzheimer's disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. Centella asiatica (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions. This study aimed to evaluate the effectiveness of CA in preventing d-galactose/aluminium chloride (d-gal/AlCl3) induced AD-like pathologies and the underlying mechanisms of action were further investigated for the first time. Results showed that co-administration of CA to d-gal/AlCl3 induced AD-like rat models significantly increased the levels of protein phosphatase 2 (PP2A) and decreased the levels of glycogen synthase kinase-3 beta (GSK-3β). It was further observed that, CA increased the expression of mRNA of Bcl-2, while there was minimal effect on the expression of caspase 3 mRNA. The results also showed that, CA prevented morphological aberrations in the connus ammonis 3 (CA 3) sub-region of the rat's hippocampus. The results clearly demonstrated for the first time that CA could alleviate d-gal/AlCl3 induced AD-like pathologies in rats via inhibition of hyperphosphorylated tau (P-tau) bio-synthetic proteins, anti-apoptosis and maintenance of cytoarchitecture.
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author Musa Chiroma, Samaila
Baharuldin, Mohamad Taufik Hidayat
Mat Taib, Che Norma
Amom, Zulkhairi
Jagadeesan, Saravanan
Adenan, Mohd Ilham
Mahdi, Onesimus
Mohd Moklas, Mohamad Aris
spellingShingle Musa Chiroma, Samaila
Baharuldin, Mohamad Taufik Hidayat
Mat Taib, Che Norma
Amom, Zulkhairi
Jagadeesan, Saravanan
Adenan, Mohd Ilham
Mahdi, Onesimus
Mohd Moklas, Mohamad Aris
Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus
author_facet Musa Chiroma, Samaila
Baharuldin, Mohamad Taufik Hidayat
Mat Taib, Che Norma
Amom, Zulkhairi
Jagadeesan, Saravanan
Adenan, Mohd Ilham
Mahdi, Onesimus
Mohd Moklas, Mohamad Aris
author_sort Musa Chiroma, Samaila
title Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus
title_short Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus
title_full Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus
title_fullStr Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus
title_full_unstemmed Centella asiatica protects d-Galactose/AlCl3 mediated alzheimers disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus
title_sort centella asiatica protects d-galactose/alcl3 mediated alzheimers disease-like rats via pp2a/gsk-3β signaling pathway in their hippocampus
publisher MDPI
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80875/1/ASIATA.pdf
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score 12.933938

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