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Co-culture systems for the production of secondary metabolites: current and future prospects

Microorganisms are the great sources of Natural Products (NPs); these are imperative to their survival apart from conferring competitiveness amongst each other within their environmental niches. Primary and secondary metabolites are the two major classes of NPs that help in cell development, where a...

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Main Authors:	Zin, Quat Tan, Hui, Yin Leow, Lee, David Charles Weerasingam, Kanakeswary, Karisnan, Song, Adelene Ai Lian, Chun, Wai Mai, Wai, Sum Yap, Swee, Hua Erin Lim, Kok, Song Lai
Format:	Article
Language:	English
Published:	Bentham Open 2019
Online Access:	http://psasir.upm.edu.my/id/eprint/80952/1/MICRO.pdf
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id	oai:psasir.upm.edu.my:80952
record_format	eprints
spelling	oai:psasir.upm.edu.my:80952 http://psasir.upm.edu.my/id/eprint/80952/ Co-culture systems for the production of secondary metabolites: current and future prospects Zin, Quat Tan Hui, Yin Leow Lee, David Charles Weerasingam Kanakeswary, Karisnan Song, Adelene Ai Lian Chun, Wai Mai Wai, Sum Yap Swee, Hua Erin Lim Kok, Song Lai Microorganisms are the great sources of Natural Products (NPs); these are imperative to their survival apart from conferring competitiveness amongst each other within their environmental niches. Primary and secondary metabolites are the two major classes of NPs that help in cell development, where antimicrobial activity is closely linked with secondary metabolites. To capitalize on the effects of secondary metabolites, co-culture methods have been often used to develop an artificial microbial community that promotes the action of these metabolites. Different analytical techniques will subsequently be employed based on the metabolite specificity and sensitivity to further enhance the metabolite induction. Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography (GC)-MS are commonly used for metabolite separation while Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) have been used as tools to elucidate the structure of compounds. This review intends to discuss current systems in use for co-culture in addition to its advantages, with discourse into the investigation of specific techniques in use for the detailed study of secondary metabolites. Further advancements and focus on co-culture technologies are required to fully realize the massive potential in synthetic biological systems. Bentham Open 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80952/1/MICRO.pdf Zin, Quat Tan and Hui, Yin Leow and Lee, David Charles Weerasingam and Kanakeswary, Karisnan and Song, Adelene Ai Lian and Chun, Wai Mai and Wai, Sum Yap and Swee, Hua Erin Lim and Kok, Song Lai (2019) Co-culture systems for the production of secondary metabolites: current and future prospects. Open Biotechnology Journal, 13. pp. 18-26. ISSN 1874-0707 https://benthamopen.com/FULLTEXT/TOBIOTJ-13-18 10.2174/1874070701913010018
institution	UPM IR
collection	UPM IR
language	English
description	Microorganisms are the great sources of Natural Products (NPs); these are imperative to their survival apart from conferring competitiveness amongst each other within their environmental niches. Primary and secondary metabolites are the two major classes of NPs that help in cell development, where antimicrobial activity is closely linked with secondary metabolites. To capitalize on the effects of secondary metabolites, co-culture methods have been often used to develop an artificial microbial community that promotes the action of these metabolites. Different analytical techniques will subsequently be employed based on the metabolite specificity and sensitivity to further enhance the metabolite induction. Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography (GC)-MS are commonly used for metabolite separation while Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) have been used as tools to elucidate the structure of compounds. This review intends to discuss current systems in use for co-culture in addition to its advantages, with discourse into the investigation of specific techniques in use for the detailed study of secondary metabolites. Further advancements and focus on co-culture technologies are required to fully realize the massive potential in synthetic biological systems.
format	Article
author	Zin, Quat Tan Hui, Yin Leow Lee, David Charles Weerasingam Kanakeswary, Karisnan Song, Adelene Ai Lian Chun, Wai Mai Wai, Sum Yap Swee, Hua Erin Lim Kok, Song Lai
spellingShingle	Zin, Quat Tan Hui, Yin Leow Lee, David Charles Weerasingam Kanakeswary, Karisnan Song, Adelene Ai Lian Chun, Wai Mai Wai, Sum Yap Swee, Hua Erin Lim Kok, Song Lai Co-culture systems for the production of secondary metabolites: current and future prospects
author_facet	Zin, Quat Tan Hui, Yin Leow Lee, David Charles Weerasingam Kanakeswary, Karisnan Song, Adelene Ai Lian Chun, Wai Mai Wai, Sum Yap Swee, Hua Erin Lim Kok, Song Lai
author_sort	Zin, Quat Tan
title	Co-culture systems for the production of secondary metabolites: current and future prospects
title_short	Co-culture systems for the production of secondary metabolites: current and future prospects
title_full	Co-culture systems for the production of secondary metabolites: current and future prospects
title_fullStr	Co-culture systems for the production of secondary metabolites: current and future prospects
title_full_unstemmed	Co-culture systems for the production of secondary metabolites: current and future prospects
title_sort	co-culture systems for the production of secondary metabolites: current and future prospects
publisher	Bentham Open
publishDate	2019
url	http://psasir.upm.edu.my/id/eprint/80952/1/MICRO.pdf
_version_	1819299701328969728
score	13.4562235

Co-culture systems for the production of secondary metabolites: current and future prospects

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