Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition
Aims: to study physiological and proteomic analysis of Stenotrophomonas maltophilia grown under iron-limited condition. Methods: one clinical and environmental S. maltophilia isolates grown under iron-depleted conditions were studied for siderophore production, ability to kill nematodes and alterati...
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Future Medicine
2019
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| Online Erişim: | http://psasir.upm.edu.my/id/eprint/81732/1/Physiological%20and%20proteomic%20analysis%20of%20Stenotrophomonas.pdf |
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oai:psasir.upm.edu.my:81732 http://psasir.upm.edu.my/id/eprint/81732/ Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition Azman, Adleen Vasodavan, Kalidasan Sither Joseph Vesudian, Narcisse Mary Subbiah, Suresh Kumar Awang Hamat, Rukman Amin Nordin, Syafinaz Wan Kamaruddin, Wan Mohd Aizat Van Belkum, Alex Neela, Vasantha Kumari Aims: to study physiological and proteomic analysis of Stenotrophomonas maltophilia grown under iron-limited condition. Methods: one clinical and environmental S. maltophilia isolates grown under iron-depleted conditions were studied for siderophore production, ability to kill nematodes and alteration in protein expression using isobaric tags for relative and absolute quantification (ITRAQ). Results & conclusions: siderophore production was observed in both clinical and environmental strains under iron-depleted conditions. Caenorhabditis elegans assay showed higher killing rate under iron-depleted (96%) compared with normal condition (76%). The proteins identified revealed, 96 proteins upregulated and 26 proteins downregulated for the two isolates under iron depletion. The upregulated proteins included several iron acquisition proteins, metabolic proteins and putative virulence proteins. Future Medicine 2019-11-28 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81732/1/Physiological%20and%20proteomic%20analysis%20of%20Stenotrophomonas.pdf Azman, Adleen and Vasodavan, Kalidasan and Sither Joseph Vesudian, Narcisse Mary and Subbiah, Suresh Kumar and Awang Hamat, Rukman and Amin Nordin, Syafinaz and Wan Kamaruddin, Wan Mohd Aizat and Van Belkum, Alex and Neela, Vasantha Kumari (2019) Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition. Future Microbiology, 14 (16). art. no. https://www.futuremedicine.com/toc/fmb/14/16. ISSN 1746-0921 10.2217/fmb-2019-0174 |
| institution |
UPM IR |
| collection |
UPM IR |
| language |
English |
| description |
Aims: to study physiological and proteomic analysis of Stenotrophomonas maltophilia grown under iron-limited condition. Methods: one clinical and environmental S. maltophilia isolates grown under iron-depleted conditions were studied for siderophore production, ability to kill nematodes and alteration in protein expression using isobaric tags for relative and absolute quantification (ITRAQ). Results & conclusions: siderophore production was observed in both clinical and environmental strains under iron-depleted conditions. Caenorhabditis elegans assay showed higher killing rate under iron-depleted (96%) compared with normal condition (76%). The proteins identified revealed, 96 proteins upregulated and 26 proteins downregulated for the two isolates under iron depletion. The upregulated proteins included several iron acquisition proteins, metabolic proteins and putative virulence proteins. |
| format |
Article |
| author |
Azman, Adleen Vasodavan, Kalidasan Sither Joseph Vesudian, Narcisse Mary Subbiah, Suresh Kumar Awang Hamat, Rukman Amin Nordin, Syafinaz Wan Kamaruddin, Wan Mohd Aizat Van Belkum, Alex Neela, Vasantha Kumari |
| spellingShingle |
Azman, Adleen Vasodavan, Kalidasan Sither Joseph Vesudian, Narcisse Mary Subbiah, Suresh Kumar Awang Hamat, Rukman Amin Nordin, Syafinaz Wan Kamaruddin, Wan Mohd Aizat Van Belkum, Alex Neela, Vasantha Kumari Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition |
| author_facet |
Azman, Adleen Vasodavan, Kalidasan Sither Joseph Vesudian, Narcisse Mary Subbiah, Suresh Kumar Awang Hamat, Rukman Amin Nordin, Syafinaz Wan Kamaruddin, Wan Mohd Aizat Van Belkum, Alex Neela, Vasantha Kumari |
| author_sort |
Azman, Adleen |
| title |
Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition |
| title_short |
Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition |
| title_full |
Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition |
| title_fullStr |
Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition |
| title_full_unstemmed |
Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition |
| title_sort |
physiological and proteomic analysis of stenotrophomonas maltophilia grown under the iron-limited condition |
| publisher |
Future Medicine |
| publishDate |
2019 |
| url |
http://psasir.upm.edu.my/id/eprint/81732/1/Physiological%20and%20proteomic%20analysis%20of%20Stenotrophomonas.pdf |
| _version_ |
1819299763630112768 |
| score |
13.4562235 |