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Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR

Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. The development of new antimicrobial agents is one of the critic...

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Main Authors: Moo, Chew Li, Yang, Shun Kai, Yusoff, Khatijah, Ajat, Mokrish, Warren, Thomas, Abushelaibi, Aisha, Lim, Swee Hua Erin, Lai, Kok Song
Format: Article
Language:English
Published: Bentham Science Publishers 2020
Online Access:http://psasir.upm.edu.my/id/eprint/86706/1/Mechanisms%20of%20antimicrobial%20resistance%20.pdf
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spelling oai:psasir.upm.edu.my:86706 http://psasir.upm.edu.my/id/eprint/86706/ Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR Moo, Chew Li Yang, Shun Kai Yusoff, Khatijah Ajat, Mokrish Warren, Thomas Abushelaibi, Aisha Lim, Swee Hua Erin Lai, Kok Song Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. The development of new antimicrobial agents is one of the critical approaches to overcome AMR. However, in the race towards developing alternative approaches to combat AMR, it appears that the scientific community is falling behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria. Although the “pioneering strategy” of discovering completely new drugs is a rational approach, the time and effort taken are considerable, the process of drug development could instead be expedited if efforts were concentrated on enhancing the efficacy of existing antimicrobials through: combination therapies; bacteriophage therapy; antimicrobial adjuvants therapy or the application of nanotechnology. This review will briefly detail the causes and mechanisms of AMR as background, and then provide insights into a novel, future emerging or evolving strategies that are currently being evaluated and which may be developed in the future to tackle the progression of AMR. Bentham Science Publishers 2020-03-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86706/1/Mechanisms%20of%20antimicrobial%20resistance%20.pdf Moo, Chew Li and Yang, Shun Kai and Yusoff, Khatijah and Ajat, Mokrish and Warren, Thomas and Abushelaibi, Aisha and Lim, Swee Hua Erin and Lai, Kok Song (2020) Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR. Current Drug Discovery Technologies, 17 (4). 430 - 447. ISSN 1570-1638; ESSN:1875-6220 https://www.eurekaselect.com/170403/article 10.2174/1570163816666190304122219
institution UPM IR
collection UPM IR
language English
description Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. The development of new antimicrobial agents is one of the critical approaches to overcome AMR. However, in the race towards developing alternative approaches to combat AMR, it appears that the scientific community is falling behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria. Although the “pioneering strategy” of discovering completely new drugs is a rational approach, the time and effort taken are considerable, the process of drug development could instead be expedited if efforts were concentrated on enhancing the efficacy of existing antimicrobials through: combination therapies; bacteriophage therapy; antimicrobial adjuvants therapy or the application of nanotechnology. This review will briefly detail the causes and mechanisms of AMR as background, and then provide insights into a novel, future emerging or evolving strategies that are currently being evaluated and which may be developed in the future to tackle the progression of AMR.
format Article
author Moo, Chew Li
Yang, Shun Kai
Yusoff, Khatijah
Ajat, Mokrish
Warren, Thomas
Abushelaibi, Aisha
Lim, Swee Hua Erin
Lai, Kok Song
spellingShingle Moo, Chew Li
Yang, Shun Kai
Yusoff, Khatijah
Ajat, Mokrish
Warren, Thomas
Abushelaibi, Aisha
Lim, Swee Hua Erin
Lai, Kok Song
Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
author_facet Moo, Chew Li
Yang, Shun Kai
Yusoff, Khatijah
Ajat, Mokrish
Warren, Thomas
Abushelaibi, Aisha
Lim, Swee Hua Erin
Lai, Kok Song
author_sort Moo, Chew Li
title Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
title_short Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
title_full Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
title_fullStr Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
title_full_unstemmed Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
title_sort mechanisms of antimicrobial resistance (amr) and alternative approaches to overcome amr
publisher Bentham Science Publishers
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/86706/1/Mechanisms%20of%20antimicrobial%20resistance%20.pdf
_version_ 1782760267135844352
score 12.935284

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