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Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies

Previous literature has reported that patients with diabetes in pregnancy (DIP) are at risk of developing antepartum depression but the results have been inconsistent in cohort studies. We conducted a systematic review and performed a meta-analysis to quantify the association between DIP and risk of...

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Κύριοι συγγραφείς: Lee, Kai Wei, Ching, Siew Mooi, Devaraj, Navin Kumar, Chong, Seng Choi, Lim, Sook Yee, Loh, Hong Chuan, Abdul Hamid, Habibah
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Multidisciplinary Digital Publishing Institute 2020
Διαθέσιμο Online:http://psasir.upm.edu.my/id/eprint/88446/1/ABSTRACT.pdf
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spelling oai:psasir.upm.edu.my:88446 http://psasir.upm.edu.my/id/eprint/88446/ Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies Lee, Kai Wei Ching, Siew Mooi Devaraj, Navin Kumar Chong, Seng Choi Lim, Sook Yee Loh, Hong Chuan Abdul Hamid, Habibah Previous literature has reported that patients with diabetes in pregnancy (DIP) are at risk of developing antepartum depression but the results have been inconsistent in cohort studies. We conducted a systematic review and performed a meta-analysis to quantify the association between DIP and risk of antepartum depression in cohort studies. Medline, Cinahl, and PubMed databases were searched for studies investigating DIP involving pregnant women with pre-existing diabetes and gestational diabetes mellitus and their risk of antepartum depression that were published in journals from inception to 27 December 2019. We derived the summary estimates using a random-effects model and reported the findings as pooled relative risks (RR) and confidence interval (CI). Publication bias was assessed using a funnel plot and was quantified by Egger and Begg’s tests. Ten studies, involving 71,036 pregnant women were included in this meta-analysis. The pooled RR to develop antepartum depression was (RR = 1.430, 95% CI: 1.251–1.636) among women with gestational diabetes mellitus. Combining pregnant women with pre-existing diabetes mellitus and gestational diabetes mellitus, they had a significant increased risk of developing antepartum depression (RR = 1.431, 95% CI: 1.205–1.699) compared with those without it. In comparison, we found no association between pre-existing diabetes mellitus in pregnancy (RR = 1.300, 95% CI: 0.736–2.297) and the risk of developing antepartum depression. This study has a few limitations: first, different questionnaire and cut-off points were used in evaluation of depression across the studies. Second, there was a lack of data on history of depression prior to pregnancy, which lead to confounding bias that could not be solved by this meta-analysis. Third, data were dominated by studies in Western countries; this is due to the studies from Eastern countries failing to meet our inclusion criteria for statistical analysis. Women with gestational diabetes mellitus have an increased risk of developing antepartum depression compared to those without the disease. Therefore, more attention on the mental health status should be given on pregnant women diagnosed with pre-existing diabetes mellitus and gestational diabetes mellitus. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88446/1/ABSTRACT.pdf Lee, Kai Wei and Ching, Siew Mooi and Devaraj, Navin Kumar and Chong, Seng Choi and Lim, Sook Yee and Loh, Hong Chuan and Abdul Hamid, Habibah (2020) Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies. International Journal of Environmental Research and Public Health, 17 (11). art. no. 3767. pp. 1-15. ISSN 1660-4601 https://www.mdpi.com/1660-4601/17/11/3767 10.3390/ijerph17113767
institution UPM IR
collection UPM IR
language English
description Previous literature has reported that patients with diabetes in pregnancy (DIP) are at risk of developing antepartum depression but the results have been inconsistent in cohort studies. We conducted a systematic review and performed a meta-analysis to quantify the association between DIP and risk of antepartum depression in cohort studies. Medline, Cinahl, and PubMed databases were searched for studies investigating DIP involving pregnant women with pre-existing diabetes and gestational diabetes mellitus and their risk of antepartum depression that were published in journals from inception to 27 December 2019. We derived the summary estimates using a random-effects model and reported the findings as pooled relative risks (RR) and confidence interval (CI). Publication bias was assessed using a funnel plot and was quantified by Egger and Begg’s tests. Ten studies, involving 71,036 pregnant women were included in this meta-analysis. The pooled RR to develop antepartum depression was (RR = 1.430, 95% CI: 1.251–1.636) among women with gestational diabetes mellitus. Combining pregnant women with pre-existing diabetes mellitus and gestational diabetes mellitus, they had a significant increased risk of developing antepartum depression (RR = 1.431, 95% CI: 1.205–1.699) compared with those without it. In comparison, we found no association between pre-existing diabetes mellitus in pregnancy (RR = 1.300, 95% CI: 0.736–2.297) and the risk of developing antepartum depression. This study has a few limitations: first, different questionnaire and cut-off points were used in evaluation of depression across the studies. Second, there was a lack of data on history of depression prior to pregnancy, which lead to confounding bias that could not be solved by this meta-analysis. Third, data were dominated by studies in Western countries; this is due to the studies from Eastern countries failing to meet our inclusion criteria for statistical analysis. Women with gestational diabetes mellitus have an increased risk of developing antepartum depression compared to those without the disease. Therefore, more attention on the mental health status should be given on pregnant women diagnosed with pre-existing diabetes mellitus and gestational diabetes mellitus.
format Article
author Lee, Kai Wei
Ching, Siew Mooi
Devaraj, Navin Kumar
Chong, Seng Choi
Lim, Sook Yee
Loh, Hong Chuan
Abdul Hamid, Habibah
spellingShingle Lee, Kai Wei
Ching, Siew Mooi
Devaraj, Navin Kumar
Chong, Seng Choi
Lim, Sook Yee
Loh, Hong Chuan
Abdul Hamid, Habibah
Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies
author_facet Lee, Kai Wei
Ching, Siew Mooi
Devaraj, Navin Kumar
Chong, Seng Choi
Lim, Sook Yee
Loh, Hong Chuan
Abdul Hamid, Habibah
author_sort Lee, Kai Wei
title Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies
title_short Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies
title_full Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies
title_fullStr Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies
title_full_unstemmed Diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies
title_sort diabetes in pregnancy and risk of antepartum depression: a systematic review and meta-analysis of cohort studies
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/88446/1/ABSTRACT.pdf
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score 13.4562235

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