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Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis

The beneficial effects of a vegetarian diet on blood pressure (BP) control have been reported in previous systematic reviews; however, so far, their relative effectiveness is not well established. Here, we performed a systematic review together with trial sequential analysis to determine the effect...

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Main Authors: Lee, Kai Wei, Loh, Hong Chuan, Siew, Mooi Ching, Devaraj, Navin Kumar, Fan, Kee Hoo
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020
Online Access:http://psasir.upm.edu.my/id/eprint/88739/1/ABSTRACT.pdf
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spelling oai:psasir.upm.edu.my:88739 http://psasir.upm.edu.my/id/eprint/88739/ Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis Lee, Kai Wei Loh, Hong Chuan Siew, Mooi Ching Devaraj, Navin Kumar Fan, Kee Hoo The beneficial effects of a vegetarian diet on blood pressure (BP) control have been reported in previous systematic reviews; however, so far, their relative effectiveness is not well established. Here, we performed a systematic review together with trial sequential analysis to determine the effect of a vegetarian diet on the reduction of blood pressure. We searched the randomized controlled trial (RCT) through Medline, PubMed and Cochrane Central Register. Fifteen eligible RCTs with 856 subjects were entered into the analysis. The pooled results demonstrated that vegetarian diet consumption significantly lowered the systolic blood pressure (weighted mean difference (WMD), −2.66 mmHg (95% confidence interval (CI) = −3.76, −1.55, p < 0.001) and diastolic BP was WMD, −1.69 95% CI = −2.97, −0.41, p < 0.001) as compared to an omnivorous diet. In subgroup analysis, a vegan diet demonstrated a greater reduction in systolic BP (WMD, −3.12 mmHg; 95% CI = −4.54, −1.70, p < 0.001) as compared with a lacto-ovo-vegetarian diet (WMD, −1.75 mmHg, 95% CI −5.38, 1.88, p = 0.05). The vegan diet has showed a similar trend in terms of diastolic blood pressure reduction (WMD, −1.92 mmHg (95% CI = −3.18, −0.66, p < 0.001) but those with a lacto-ovo-vegetarian diet showed no changes in diastolic BP reduction (WMD, 0.00, 95% CI = 0.00, 0.00), p = 0.432). In conclusion, vegetarian diets are associated with significant reductions in BP compared with omnivorous diets, suggesting that they may play a key role in the primary prevention and overall management of hypertension. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88739/1/ABSTRACT.pdf Lee, Kai Wei and Loh, Hong Chuan and Siew, Mooi Ching and Devaraj, Navin Kumar and Fan, Kee Hoo (2020) Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis. Nutrients, 12 (6). pp. 1-17. ISSN 2072-6643 http://mdpi.com/2072-6643/12/6/1604 10.3390/nu12061604
institution UPM IR
collection UPM IR
language English
description The beneficial effects of a vegetarian diet on blood pressure (BP) control have been reported in previous systematic reviews; however, so far, their relative effectiveness is not well established. Here, we performed a systematic review together with trial sequential analysis to determine the effect of a vegetarian diet on the reduction of blood pressure. We searched the randomized controlled trial (RCT) through Medline, PubMed and Cochrane Central Register. Fifteen eligible RCTs with 856 subjects were entered into the analysis. The pooled results demonstrated that vegetarian diet consumption significantly lowered the systolic blood pressure (weighted mean difference (WMD), −2.66 mmHg (95% confidence interval (CI) = −3.76, −1.55, p < 0.001) and diastolic BP was WMD, −1.69 95% CI = −2.97, −0.41, p < 0.001) as compared to an omnivorous diet. In subgroup analysis, a vegan diet demonstrated a greater reduction in systolic BP (WMD, −3.12 mmHg; 95% CI = −4.54, −1.70, p < 0.001) as compared with a lacto-ovo-vegetarian diet (WMD, −1.75 mmHg, 95% CI −5.38, 1.88, p = 0.05). The vegan diet has showed a similar trend in terms of diastolic blood pressure reduction (WMD, −1.92 mmHg (95% CI = −3.18, −0.66, p < 0.001) but those with a lacto-ovo-vegetarian diet showed no changes in diastolic BP reduction (WMD, 0.00, 95% CI = 0.00, 0.00), p = 0.432). In conclusion, vegetarian diets are associated with significant reductions in BP compared with omnivorous diets, suggesting that they may play a key role in the primary prevention and overall management of hypertension.
format Article
author Lee, Kai Wei
Loh, Hong Chuan
Siew, Mooi Ching
Devaraj, Navin Kumar
Fan, Kee Hoo
spellingShingle Lee, Kai Wei
Loh, Hong Chuan
Siew, Mooi Ching
Devaraj, Navin Kumar
Fan, Kee Hoo
Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis
author_facet Lee, Kai Wei
Loh, Hong Chuan
Siew, Mooi Ching
Devaraj, Navin Kumar
Fan, Kee Hoo
author_sort Lee, Kai Wei
title Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis
title_short Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis
title_full Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis
title_fullStr Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis
title_full_unstemmed Effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis
title_sort effects of vegetarian diets on blood pressure lowering: a systematic review with meta‐analysis and trial sequential analysis
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/88739/1/ABSTRACT.pdf
_version_ 1782760578676162560
score 12.935284

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