Wersja MARC: Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine

Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine

Caseous lymphadenitis (CLA) caused by Corynebacterium pseudotuberculosis is characterized by the development of abscesses, mainly in superficial and internal lymph nodes, visceral and reproductive organs in small ruminants. This study aims to examine the histopathological changes in reproductive org...

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Główni autorzy:	Umer, Muhammad, Abdullah, Faez Firdaus Jesse, Mohammed Saleh, Wessam Monther, Lim, Eric Teik Chung, Haron, Abd Wahid, Saharee, Abdul Aziz, Mohd Lila, Mohd Azmi, Ariff, Arbakariya, Mohammad, Konto, Sharif, Aamir
Format:	Artykuł
Język:	English
Wydane:	Elsevier 2020
Dostęp online:	http://psasir.upm.edu.my/id/eprint/89194/1/ORGAN.pdf
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spelling	oai:psasir.upm.edu.my:89194 http://psasir.upm.edu.my/id/eprint/89194/ Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine Umer, Muhammad Abdullah, Faez Firdaus Jesse Mohammed Saleh, Wessam Monther Lim, Eric Teik Chung Haron, Abd Wahid Saharee, Abdul Aziz Mohd Lila, Mohd Azmi Ariff, Arbakariya Mohammad, Konto Sharif, Aamir Caseous lymphadenitis (CLA) caused by Corynebacterium pseudotuberculosis is characterized by the development of abscesses, mainly in superficial and internal lymph nodes, visceral and reproductive organs in small ruminants. This study aims to examine the histopathological changes in reproductive organs of goats immunized with killed vaccine of C. pseudotuberculosis. In this study, twenty four (24) clinically healthy bucks and does were divided into four groups A, B, C and D. Animals in groups A and B were immunized with 0.5 and 1% formalin killed vaccine, respectively; followed by a booster dose. After the booster dose of immunization, groups A, B and C were challenged with C. pseudotuberculosis at 106 cfu/ml. Goats in group D were immunize and unchallenged and left as control group. All C. pseudotuberculosis infected animals were euthanized humanely 12 weeks post-challenged. Tissue samples such as testes, epididymis, spermatic cord, penis, pituitary gland, mammary gland, vulva, vagina, cervix, uterus, fallopian tube and ovaries were collected for histopathology study. Microscopic examination of all tissues (testes, seminiferous tubules, spermatic cord, penile tissues and the pituitary gland) in the male reproductive organs of the bucks that were inoculated with 2 ml of 0.5% and 1.0% of C. pseudotuberculosis killed vaccine showed normal (animals inoculated with 1.0%) to mild (animals inoculated with 0.5%) histopathological changes when compared with those from group C which showed varying degrees of histopathological changes (p < 0.01) in their various tissues. For the female does, similar histopathological changes were observed for the various tissues examined (ovaries, fallopian tubes, uterine horns, uterine tissues, cervix, vaginal, vulva, mammary glands and the pituitary glands) in which the vaccinated groups A &B showed a significantly (p < 0.001) less histopathological changes when compared with those in group C that showed varying degrees of histopathological changes in the reproductive organs investigated. This study showed the efficacy of C. pseudotuberculosis killed vaccine protecting against reproductive tissue damages cause by the active infection with the live bacteria in both bucks and does in the study area. Elsevier 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89194/1/ORGAN.pdf Umer, Muhammad and Abdullah, Faez Firdaus Jesse and Mohammed Saleh, Wessam Monther and Lim, Eric Teik Chung and Haron, Abd Wahid and Saharee, Abdul Aziz and Mohd Lila, Mohd Azmi and Ariff, Arbakariya and Mohammad, Konto and Sharif, Aamir (2020) Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine. Microbial Pathogenesis, 149. art. no. 104539. pp. 1-12. ISSN 0882-4010; ESSN: 1096-1208 https://www.sciencedirect.com/science/article/pii/S0882401020309050 10.1016/j.micpath.2020.104539
institution	UPM IR
collection	UPM IR
language	English
description	Caseous lymphadenitis (CLA) caused by Corynebacterium pseudotuberculosis is characterized by the development of abscesses, mainly in superficial and internal lymph nodes, visceral and reproductive organs in small ruminants. This study aims to examine the histopathological changes in reproductive organs of goats immunized with killed vaccine of C. pseudotuberculosis. In this study, twenty four (24) clinically healthy bucks and does were divided into four groups A, B, C and D. Animals in groups A and B were immunized with 0.5 and 1% formalin killed vaccine, respectively; followed by a booster dose. After the booster dose of immunization, groups A, B and C were challenged with C. pseudotuberculosis at 106 cfu/ml. Goats in group D were immunize and unchallenged and left as control group. All C. pseudotuberculosis infected animals were euthanized humanely 12 weeks post-challenged. Tissue samples such as testes, epididymis, spermatic cord, penis, pituitary gland, mammary gland, vulva, vagina, cervix, uterus, fallopian tube and ovaries were collected for histopathology study. Microscopic examination of all tissues (testes, seminiferous tubules, spermatic cord, penile tissues and the pituitary gland) in the male reproductive organs of the bucks that were inoculated with 2 ml of 0.5% and 1.0% of C. pseudotuberculosis killed vaccine showed normal (animals inoculated with 1.0%) to mild (animals inoculated with 0.5%) histopathological changes when compared with those from group C which showed varying degrees of histopathological changes (p < 0.01) in their various tissues. For the female does, similar histopathological changes were observed for the various tissues examined (ovaries, fallopian tubes, uterine horns, uterine tissues, cervix, vaginal, vulva, mammary glands and the pituitary glands) in which the vaccinated groups A &B showed a significantly (p < 0.001) less histopathological changes when compared with those in group C that showed varying degrees of histopathological changes in the reproductive organs investigated. This study showed the efficacy of C. pseudotuberculosis killed vaccine protecting against reproductive tissue damages cause by the active infection with the live bacteria in both bucks and does in the study area.
format	Article
author	Umer, Muhammad Abdullah, Faez Firdaus Jesse Mohammed Saleh, Wessam Monther Lim, Eric Teik Chung Haron, Abd Wahid Saharee, Abdul Aziz Mohd Lila, Mohd Azmi Ariff, Arbakariya Mohammad, Konto Sharif, Aamir
spellingShingle	Umer, Muhammad Abdullah, Faez Firdaus Jesse Mohammed Saleh, Wessam Monther Lim, Eric Teik Chung Haron, Abd Wahid Saharee, Abdul Aziz Mohd Lila, Mohd Azmi Ariff, Arbakariya Mohammad, Konto Sharif, Aamir Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine
author_facet	Umer, Muhammad Abdullah, Faez Firdaus Jesse Mohammed Saleh, Wessam Monther Lim, Eric Teik Chung Haron, Abd Wahid Saharee, Abdul Aziz Mohd Lila, Mohd Azmi Ariff, Arbakariya Mohammad, Konto Sharif, Aamir
author_sort	Umer, Muhammad
title	Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine
title_short	Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine
title_full	Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine
title_fullStr	Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine
title_full_unstemmed	Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine
title_sort	histopathological changes of reproductive organs of goats immunized with corynebacterium pseudotuberculosis killed vaccine
publisher	Elsevier
publishDate	2020
url	http://psasir.upm.edu.my/id/eprint/89194/1/ORGAN.pdf
_version_	1819300316161507328
score	13.4562235

Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine

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