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Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus

This study aimed to identify the independent and combined effects of age, BMI at first prenatal visit and GWG on the risk of GDM. A retrospective cohort study of 1,951 pregnant women in Seremban district, Negeri Sembilan, Malaysia. GDM was defined as fasting plasma glucose (FPG) ≥5.6 mmol/l and/or 2...

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Main Authors: Yong, Heng Yaw, Mohd Shariff, Zalilah, Mohd Yusof, Barakatun Nisak, Rejali, Zulida, Tee, Yvonne Yee Siang, Bindels, Jacques, van der Beek, Eline M.
Format: Article
Language:English
Published: Nature Publishing Group 2020
Online Access:http://psasir.upm.edu.my/id/eprint/89342/1/AGE.pdf
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spelling oai:psasir.upm.edu.my:89342 http://psasir.upm.edu.my/id/eprint/89342/ Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus Yong, Heng Yaw Mohd Shariff, Zalilah Mohd Yusof, Barakatun Nisak Rejali, Zulida Tee, Yvonne Yee Siang Bindels, Jacques van der Beek, Eline M. This study aimed to identify the independent and combined effects of age, BMI at first prenatal visit and GWG on the risk of GDM. A retrospective cohort study of 1,951 pregnant women in Seremban district, Negeri Sembilan, Malaysia. GDM was defined as fasting plasma glucose (FPG) ≥5.6 mmol/l and/or 2-hour postprandial plasma glucose (2hPPG) ≥7.8 mmol/l. A higher percentage of women with GDM had 2 risk factors (29.0%) or >2 risk factors (8.6%) compared to non-GDM women (2 risk factors: 25.5%; >2 risk factors: 5.0%). In general, women with ≥2 risk factors were respectively 1.36-2.06 times more likely to have GDM compared to those without risk factors. Older maternal age and being overweight/obese were significantly associated with risk of GDM. Overweight/obese women with age ≥35 years had 2.45 times higher risk of GDM and having excessive GWG at second trimester further increased the risk of GDM. Age and BMI are independent risk factors for GDM but not GWG in the first and second trimester. The findings emphasize the need to focus on a healthy BMI before pregnancy and optimal GWG during pregnancy to improve pregnancy outcomes. Nature Publishing Group 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89342/1/AGE.pdf Yong, Heng Yaw and Mohd Shariff, Zalilah and Mohd Yusof, Barakatun Nisak and Rejali, Zulida and Tee, Yvonne Yee Siang and Bindels, Jacques and van der Beek, Eline M. (2020) Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus. Scientific Reports, 10 (1). art. no. 8486. pp. 1-16. ISSN 2045-2322 https://www.mdpi.com/2073-4360/12/9/1951 10.1038/s41598-020-65251-2
institution UPM IR
collection UPM IR
language English
description This study aimed to identify the independent and combined effects of age, BMI at first prenatal visit and GWG on the risk of GDM. A retrospective cohort study of 1,951 pregnant women in Seremban district, Negeri Sembilan, Malaysia. GDM was defined as fasting plasma glucose (FPG) ≥5.6 mmol/l and/or 2-hour postprandial plasma glucose (2hPPG) ≥7.8 mmol/l. A higher percentage of women with GDM had 2 risk factors (29.0%) or >2 risk factors (8.6%) compared to non-GDM women (2 risk factors: 25.5%; >2 risk factors: 5.0%). In general, women with ≥2 risk factors were respectively 1.36-2.06 times more likely to have GDM compared to those without risk factors. Older maternal age and being overweight/obese were significantly associated with risk of GDM. Overweight/obese women with age ≥35 years had 2.45 times higher risk of GDM and having excessive GWG at second trimester further increased the risk of GDM. Age and BMI are independent risk factors for GDM but not GWG in the first and second trimester. The findings emphasize the need to focus on a healthy BMI before pregnancy and optimal GWG during pregnancy to improve pregnancy outcomes.
format Article
author Yong, Heng Yaw
Mohd Shariff, Zalilah
Mohd Yusof, Barakatun Nisak
Rejali, Zulida
Tee, Yvonne Yee Siang
Bindels, Jacques
van der Beek, Eline M.
spellingShingle Yong, Heng Yaw
Mohd Shariff, Zalilah
Mohd Yusof, Barakatun Nisak
Rejali, Zulida
Tee, Yvonne Yee Siang
Bindels, Jacques
van der Beek, Eline M.
Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus
author_facet Yong, Heng Yaw
Mohd Shariff, Zalilah
Mohd Yusof, Barakatun Nisak
Rejali, Zulida
Tee, Yvonne Yee Siang
Bindels, Jacques
van der Beek, Eline M.
author_sort Yong, Heng Yaw
title Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus
title_short Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus
title_full Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus
title_fullStr Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus
title_full_unstemmed Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus
title_sort independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus
publisher Nature Publishing Group
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/89342/1/AGE.pdf
_version_ 1819300328901705728
score 13.4562235

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