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Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA

Cancer is a complex multifactorial disease and leading causes of death worldwide. Despite the development of many anticancer drugs, there is a reduced survival rate due to severe side effects. The nontargeted approach of convention drugs is one of the leading players in context to toxicity. Hyaluron...

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Main Authors: Chaudhry, Gul E. Saba, Akim, Abdah, Zafar, Muhammad Naveed, M. A., Abdullah, Yeong, Yik Sung, Tengku Muhammad, Tengku Sifzizul
Formáid: Article
Teanga:English
Foilsithe: Medknow Publications 2020
Rochtain Ar Líne:http://psasir.upm.edu.my/id/eprint/89346/1/AKT.pdf
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spelling oai:psasir.upm.edu.my:89346 http://psasir.upm.edu.my/id/eprint/89346/ Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA Chaudhry, Gul E. Saba Akim, Abdah Zafar, Muhammad Naveed M. A., Abdullah Yeong, Yik Sung Tengku Muhammad, Tengku Sifzizul Cancer is a complex multifactorial disease and leading causes of death worldwide. Despite the development of many anticancer drugs, there is a reduced survival rate due to severe side effects. The nontargeted approach of convention drugs is one of the leading players in context to toxicity. Hyaluronan is a versatile bio-polymer and ligand of the receptor (CD44) on cancer cells. The MCF-7 and HT-29 cancer cell lines treated with hyaluronic acid-paclitaxel (HA-PTX) showed the distinguishing morphological features of apoptosis. Flow cytometric analysis showed that HA-PTX induces apoptosis as a significant mode of cell death. The activation level of tumor suppressor protein (p53) increased after PTX treatment in MCF-7, but no changes observed in HT-29 might be due to hereditary mutations. The lack of suppression in AKT and Rho A protein suggest the use of possible inhibitors in future studies which might could play a role in increasing the sensitivity of drug towards mutated cells line and reducing the possibilities for cancer cell survival, migration, and metastasis. Medknow Publications 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89346/1/AKT.pdf Chaudhry, Gul E. Saba and Akim, Abdah and Zafar, Muhammad Naveed and M. A., Abdullah and Yeong, Yik Sung and Tengku Muhammad, Tengku Sifzizul (2020) Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA. Journal of Advanced Pharmaceutical Technology and Research, 11 (3). 101 - 106. ISSN 0110-5558; ESSN: 0976-2094 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574732/ 10.4103/japtr.JAPTR_26_20
institution UPM IR
collection UPM IR
language English
description Cancer is a complex multifactorial disease and leading causes of death worldwide. Despite the development of many anticancer drugs, there is a reduced survival rate due to severe side effects. The nontargeted approach of convention drugs is one of the leading players in context to toxicity. Hyaluronan is a versatile bio-polymer and ligand of the receptor (CD44) on cancer cells. The MCF-7 and HT-29 cancer cell lines treated with hyaluronic acid-paclitaxel (HA-PTX) showed the distinguishing morphological features of apoptosis. Flow cytometric analysis showed that HA-PTX induces apoptosis as a significant mode of cell death. The activation level of tumor suppressor protein (p53) increased after PTX treatment in MCF-7, but no changes observed in HT-29 might be due to hereditary mutations. The lack of suppression in AKT and Rho A protein suggest the use of possible inhibitors in future studies which might could play a role in increasing the sensitivity of drug towards mutated cells line and reducing the possibilities for cancer cell survival, migration, and metastasis.
format Article
author Chaudhry, Gul E. Saba
Akim, Abdah
Zafar, Muhammad Naveed
M. A., Abdullah
Yeong, Yik Sung
Tengku Muhammad, Tengku Sifzizul
spellingShingle Chaudhry, Gul E. Saba
Akim, Abdah
Zafar, Muhammad Naveed
M. A., Abdullah
Yeong, Yik Sung
Tengku Muhammad, Tengku Sifzizul
Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
author_facet Chaudhry, Gul E. Saba
Akim, Abdah
Zafar, Muhammad Naveed
M. A., Abdullah
Yeong, Yik Sung
Tengku Muhammad, Tengku Sifzizul
author_sort Chaudhry, Gul E. Saba
title Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
title_short Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
title_full Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
title_fullStr Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
title_full_unstemmed Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
title_sort induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of akt and rhoa
publisher Medknow Publications
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/89346/1/AKT.pdf
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score 13.4562235

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