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The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model

The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC) via a chemical nociceptive model in mice. The a...

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Main Authors: Hui, Ming Ong, Ahmad Azmi, Ahmad Farhan, Sze, Wei Leong, Abas, Faridah, Perimal, Enoch Kumar, Omar Farouk, Ahmad Akira, Israf Ali, Daud Ahmad, Sulaiman, Mohd Roslan
Format: Article
Language:English
Published: MDPI AG 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95511/1/The%20involvement%20of%20L-arginine-nitric%20ox-ide-cGMP-ATP-sensitive%20K%2B%20channel%20pathway%20in%20antinocicep-tion%20of%20BBHC%2C%20a%20novel%20diarylpentanoid%20analogue%2C%20in%20mice%20model.pdf
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spelling oai:psasir.upm.edu.my:95511 http://psasir.upm.edu.my/id/eprint/95511/ The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model Hui, Ming Ong Ahmad Azmi, Ahmad Farhan Sze, Wei Leong Abas, Faridah Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC) via a chemical nociceptive model in mice. The antinociceptive action of BBHC (1 mg/kg, i.p.) was attenuated by the intraperitoneal pre-treatment of l-arginine (a nitric oxide synthase precursor) and glibenclamide (an ATP-sensitive K+ channel blocker) in acetic acid-induced abdominal constriction tests. Interestingly, BBHC’s antinociception was significantly enhanced by the i.p. pre-treatment of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a selective inhibitor of soluble guanylyl cyclase (p < 0.05). Altogether, these findings suggest that the systemic administration of BBHC is able to establish a significant antinociceptive effect in a mice model of chemically induced pain. BBHC’s antinociception is shown to be mediated by the involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway, without any potential sedative or muscle relaxant concerns. MDPI AG 2021-12-08 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/95511/1/The%20involvement%20of%20L-arginine-nitric%20ox-ide-cGMP-ATP-sensitive%20K%2B%20channel%20pathway%20in%20antinocicep-tion%20of%20BBHC%2C%20a%20novel%20diarylpentanoid%20analogue%2C%20in%20mice%20model.pdf Hui, Ming Ong and Ahmad Azmi, Ahmad Farhan and Sze, Wei Leong and Abas, Faridah and Perimal, Enoch Kumar and Omar Farouk, Ahmad Akira and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2021) The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model. MOLECULES, 26 (24). art. no. 7431. pp. 1-11. ISSN 1431-5165; ESSN: 1420-3049 https://www.mdpi.com/1420-3049/26/24/7431 10.3390/molecules26247431
institution UPM IR
collection UPM IR
language English
description The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC) via a chemical nociceptive model in mice. The antinociceptive action of BBHC (1 mg/kg, i.p.) was attenuated by the intraperitoneal pre-treatment of l-arginine (a nitric oxide synthase precursor) and glibenclamide (an ATP-sensitive K+ channel blocker) in acetic acid-induced abdominal constriction tests. Interestingly, BBHC’s antinociception was significantly enhanced by the i.p. pre-treatment of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a selective inhibitor of soluble guanylyl cyclase (p < 0.05). Altogether, these findings suggest that the systemic administration of BBHC is able to establish a significant antinociceptive effect in a mice model of chemically induced pain. BBHC’s antinociception is shown to be mediated by the involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway, without any potential sedative or muscle relaxant concerns.
format Article
author Hui, Ming Ong
Ahmad Azmi, Ahmad Farhan
Sze, Wei Leong
Abas, Faridah
Perimal, Enoch Kumar
Omar Farouk, Ahmad Akira
Israf Ali, Daud Ahmad
Sulaiman, Mohd Roslan
spellingShingle Hui, Ming Ong
Ahmad Azmi, Ahmad Farhan
Sze, Wei Leong
Abas, Faridah
Perimal, Enoch Kumar
Omar Farouk, Ahmad Akira
Israf Ali, Daud Ahmad
Sulaiman, Mohd Roslan
The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
author_facet Hui, Ming Ong
Ahmad Azmi, Ahmad Farhan
Sze, Wei Leong
Abas, Faridah
Perimal, Enoch Kumar
Omar Farouk, Ahmad Akira
Israf Ali, Daud Ahmad
Sulaiman, Mohd Roslan
author_sort Hui, Ming Ong
title The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
title_short The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
title_full The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
title_fullStr The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
title_full_unstemmed The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
title_sort involvement of l-arginine-nitric ox-ide-cgmp-atp-sensitive k+ channel pathway in antinocicep-tion of bbhc, a novel diarylpentanoid analogue, in mice model
publisher MDPI AG
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95511/1/The%20involvement%20of%20L-arginine-nitric%20ox-ide-cGMP-ATP-sensitive%20K%2B%20channel%20pathway%20in%20antinocicep-tion%20of%20BBHC%2C%20a%20novel%20diarylpentanoid%20analogue%2C%20in%20mice%20model.pdf
_version_ 1819300789248589824
score 13.4562235

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