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Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival

Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated Candida species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence is primarily due to an increase in the acquired immunodef...

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Main Authors: Hassan, Yahaya, Chew, Shu Yih, Thian, Leslie Lung Than
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2021
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spelling oai:psasir.upm.edu.my:96276 http://psasir.upm.edu.my/id/eprint/96276/ Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival Hassan, Yahaya Chew, Shu Yih Thian, Leslie Lung Than Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated Candida species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. The elderly population and the frequent use of indwelling medical devices are also predisposing factors. This work aimed to review various virulence factors that facilitate the survival of pathogenic C. glabrata in IC. The available published research articles related to the pathogenicity of C. glabrata were retrieved and reviewed from four credible databases, mainly Google Scholar, ScienceDirect, PubMed, and Scopus. The articles highlighted many virulence factors associated with pathogenicity in C. glabrata, including adherence to susceptible host surfaces, evading host defences, replicative ageing, and producing hydrolytic enzymes (e.g., phospholipases, proteases, and haemolysins). The factors facilitate infection initiation. Other virulent factors include iron regulation and genetic mutations. Accordingly, biofilm production, tolerance to high-stress environments, resistance to neutrophil killings, and development of resistance to antifungal drugs, notably to fluconazole and other azole derivatives, were reported. The review provided evident pathogenic mechanisms and antifungal resistance associated with C. glabrata in ensuring its sustenance and survival. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Hassan, Yahaya and Chew, Shu Yih and Thian, Leslie Lung Than (2021) Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival. Journal of Fungi, 7 (8). art. no. 667. pp. 1-18. ISSN 2309-608X https://www.mdpi.com/2309-608X/7/8/667 10.3390/jof7080667
institution UPM IR
collection UPM IR
description Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated Candida species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. The elderly population and the frequent use of indwelling medical devices are also predisposing factors. This work aimed to review various virulence factors that facilitate the survival of pathogenic C. glabrata in IC. The available published research articles related to the pathogenicity of C. glabrata were retrieved and reviewed from four credible databases, mainly Google Scholar, ScienceDirect, PubMed, and Scopus. The articles highlighted many virulence factors associated with pathogenicity in C. glabrata, including adherence to susceptible host surfaces, evading host defences, replicative ageing, and producing hydrolytic enzymes (e.g., phospholipases, proteases, and haemolysins). The factors facilitate infection initiation. Other virulent factors include iron regulation and genetic mutations. Accordingly, biofilm production, tolerance to high-stress environments, resistance to neutrophil killings, and development of resistance to antifungal drugs, notably to fluconazole and other azole derivatives, were reported. The review provided evident pathogenic mechanisms and antifungal resistance associated with C. glabrata in ensuring its sustenance and survival.
format Article
author Hassan, Yahaya
Chew, Shu Yih
Thian, Leslie Lung Than
spellingShingle Hassan, Yahaya
Chew, Shu Yih
Thian, Leslie Lung Than
Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
author_facet Hassan, Yahaya
Chew, Shu Yih
Thian, Leslie Lung Than
author_sort Hassan, Yahaya
title Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
title_short Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
title_full Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
title_fullStr Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
title_full_unstemmed Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
title_sort candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
_version_ 1819300839134593024
score 13.4562235

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