Cover Image

Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters

The potential of producing L-isoleucine crystals with the aid of electric potential and its effect on the nucleation kinetics of L-isoleucine were probed using polythermal and isothermal crystallisation techniques, assisted with 5 V, 9 V, and 20 V electric potentials. The polythermal experiments wer...

Full description

Saved in:
Bibliographic Details
Main Authors: Md Azmi, Nik Salwani, Anuar, Nornizar, Othman, Muhamad Fitri, Abu Bakar, Noor Fitrah, Naim, Mohd Nazli
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/97048/1/ABSTRACT.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:psasir.upm.edu.my:97048
record_format eprints
spelling oai:psasir.upm.edu.my:97048 http://psasir.upm.edu.my/id/eprint/97048/ Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters Md Azmi, Nik Salwani Anuar, Nornizar Othman, Muhamad Fitri Abu Bakar, Noor Fitrah Naim, Mohd Nazli The potential of producing L-isoleucine crystals with the aid of electric potential and its effect on the nucleation kinetics of L-isoleucine were probed using polythermal and isothermal crystallisation techniques, assisted with 5 V, 9 V, and 20 V electric potentials. The polythermal experiments were conducted with cooling rates of 0.1 °C/min–0.7 °C/min, whilst isothermal crystallisation was conducted with a supersaturation of 1.30–1.70, and both were carried out in a 200 mL temperature-controlled jacketed reactor. Prediction of the nucleation rate and its associated parameters for isothermal crystallisation was carried out using a molecular dynamics simulation. In both crystallisation techniques, electric potentials increased the nucleation rate, but the intensity of the electric potential had less impact on the measured parameters. Nucleation rates for 5 V isothermal crystallisation were in the order of 1010 higher than for polythermal crystallisation. Electric potential doubled the nucleation rates for polythermal crystallisation and increased the nucleation rates 12-fold in isothermal crystallisation. The isothermal technique produced the form B polymorph, but mixtures of forms A and B were produced in polythermal crystallisation. The predicted critical number of molecules, N*, and the critical radius, r*, were in good agreement with the experimental data, with a higher predicted nucleation rate in the order of 102 Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97048/1/ABSTRACT.pdf Md Azmi, Nik Salwani and Anuar, Nornizar and Othman, Muhamad Fitri and Abu Bakar, Noor Fitrah and Naim, Mohd Nazli (2021) Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters. Crystals, 11 (6). art. no. 620. pp. 1-20. ISSN 2073-4352 https://www.mdpi.com/2073-4352/11/6/620 10.3390/cryst11060620
institution UPM IR
collection UPM IR
language English
description The potential of producing L-isoleucine crystals with the aid of electric potential and its effect on the nucleation kinetics of L-isoleucine were probed using polythermal and isothermal crystallisation techniques, assisted with 5 V, 9 V, and 20 V electric potentials. The polythermal experiments were conducted with cooling rates of 0.1 °C/min–0.7 °C/min, whilst isothermal crystallisation was conducted with a supersaturation of 1.30–1.70, and both were carried out in a 200 mL temperature-controlled jacketed reactor. Prediction of the nucleation rate and its associated parameters for isothermal crystallisation was carried out using a molecular dynamics simulation. In both crystallisation techniques, electric potentials increased the nucleation rate, but the intensity of the electric potential had less impact on the measured parameters. Nucleation rates for 5 V isothermal crystallisation were in the order of 1010 higher than for polythermal crystallisation. Electric potential doubled the nucleation rates for polythermal crystallisation and increased the nucleation rates 12-fold in isothermal crystallisation. The isothermal technique produced the form B polymorph, but mixtures of forms A and B were produced in polythermal crystallisation. The predicted critical number of molecules, N*, and the critical radius, r*, were in good agreement with the experimental data, with a higher predicted nucleation rate in the order of 102
format Article
author Md Azmi, Nik Salwani
Anuar, Nornizar
Othman, Muhamad Fitri
Abu Bakar, Noor Fitrah
Naim, Mohd Nazli
spellingShingle Md Azmi, Nik Salwani
Anuar, Nornizar
Othman, Muhamad Fitri
Abu Bakar, Noor Fitrah
Naim, Mohd Nazli
Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters
author_facet Md Azmi, Nik Salwani
Anuar, Nornizar
Othman, Muhamad Fitri
Abu Bakar, Noor Fitrah
Naim, Mohd Nazli
author_sort Md Azmi, Nik Salwani
title Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters
title_short Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters
title_full Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters
title_fullStr Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters
title_full_unstemmed Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters
title_sort electric-potential-assisted crystallisation of l-isoleucine: a study of nucleation kinetics and its associated parameters
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97048/1/ABSTRACT.pdf
_version_ 1819300899639525376
score 13.4562235

Similar Items