Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets /
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton :
CRC Press,
2007.
|
| Edition: | 2nd ed. |
| Subjects: | |
| Online Access: | Publisher description |
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| 100 | 1 | |a Boelsterli, Urs A., |d 1948- . | |
| 245 | 1 | 0 | |a Mechanistic toxicology : |b the molecular basis of how chemicals disrupt biological targets / |c Urs A. Boelsterli. |
| 250 | |a 2nd ed. | ||
| 260 | |a Boca Raton : |b CRC Press, |c 2007. | ||
| 300 | |a 399p. : |b ill. ; |c 24cm. | ||
| 505 | 0 | 0 | |a Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. |
| 650 | 0 | |a Molecular toxicology. | |
| 650 | 0 | |a Toxicology |x methods. | |
| 650 | 0 | |a Molecular Biology |x methods. | |
| 650 | 0 | |a Signal Transduction. | |
| 650 | 0 | |a Xenobiotics |x pharmacokinetics. | |
| 650 | 0 | |a Xenobiotics |x toxicity. | |
| 856 | 4 | 2 | |3 Publisher description |u http://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html |
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