Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets /
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton :
CRC Press,
2007.
|
| Edition: | 2nd ed. |
| Subjects: | |
| Online Access: | Publisher description |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Types of toxic responses
- Organ-selective toxicity
- Cellular transport and selective accumulation of potentially toxic xenobiotics
- Bioactivation of xenobiotics to reactive metabolites
- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation
- Disruption of cellular calcium homeostasis
- Mechanisms of necrotic and apoptotic cell death
- Impairment of cell proliferation and tissue repair
- Covalent binding of reactive metabolites to cellular macromolecules
- Immune mechanisms
- Cytokine-mediated toxicity
- Specific inactivation of enzymes and other proteins
- Interactions of xenobiotics with ion transporters
- Nuclear receptor-mediated toxicity
- Activation or disruption of cellular signal transduction by xenobiotics
- Disruption of mitochondrial function and mitochondria-mediated toxicity
- Novel mechanisms derived from systems toxicology.