Approaches to the conformational analysis of biopharmaceuticals /
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton :
CRC Press,
c2010.
|
| Series: | Protein science series.
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| Subjects: | |
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| 020 | |a 9781439807804 (hbk) | ||
| 020 | |a 1439807809 (hbk) | ||
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| 100 | 1 | |a Lundblad, Roger L. | |
| 245 | 1 | 0 | |a Approaches to the conformational analysis of biopharmaceuticals / |c Roger L. Lundblad. |
| 260 | |a Boca Raton : |b CRC Press, |c c2010. | ||
| 300 | |a xiii, 354p. : |b ill. ; |c 25cm. | ||
| 490 | 1 | |a Protein science series. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Introduction to biopharmaceutical conformational analysis : issues and methods -- Comparability of biotechnological/biological products and biological generics -- Application of native electrophoresis for the study of protein conformation -- Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation -- Size-exclusion chromatography and bimolecular conformation -- Use of analytical ultracentrifugation to study biomolecular conformation -- Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules -- Light scattering and biomacromolecular conformation -- Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products -- Near-infrared spectroscopy and macromolecular conformation -- Use of mid-infrared and Fourier transform infrared spectroscopy to study conformation of biomacromolecules -- Use of Raman spectroscopy to evaluate biopharmaceutical conformation -- The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products -- Use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation -- Use of nuclear magnetic resonance for the characterization of biotherapeutic products -- Use of chemical probes for the study of protein conformation -- Use of hydrogen exchange in the study of biopharmaceutical conformation -- Use of chemical modification for the conformational analysis of biopharmaceuticals -- Use of immunology to characterize biopharmaceutical conformation -- Use of limited proteolysis to study the conformation of proteins of biotechnological interest -- Other technologies for the characterization of conformational change in biopharmaceuticals -- Development of an experimental approach for the study of the conformation of a biological therapeutic product. | |
| 650 | 0 | |a Protein drugs |x Conformation. | |
| 650 | 0 | |a Pharmaceutical biotechnology. | |
| 650 | 1 | 2 | |a Biopharmaceutics |x methods. |
| 650 | 2 | 2 | |a Protein Conformation. |
| 650 | 2 | 2 | |a Proteins |x Analysis. |
| 830 | 0 | |a Protein science series. | |
| 942 | |2 lcc |c 20000 | ||
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