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Approaches to the conformational analysis of biopharmaceuticals /

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Bibliographic Details
Main Author: Lundblad, Roger L.
Format: Book
Language:English
Published: Boca Raton : CRC Press, c2010.
Series:Protein science series.
Subjects:
Protein drugs > Conformation.
Pharmaceutical biotechnology.
Biopharmaceutics > methods.
Protein Conformation.
Proteins > Analysis.
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Table of Contents:
  • Introduction to biopharmaceutical conformational analysis : issues and methods
  • Comparability of biotechnological/biological products and biological generics
  • Application of native electrophoresis for the study of protein conformation
  • Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation
  • Size-exclusion chromatography and bimolecular conformation
  • Use of analytical ultracentrifugation to study biomolecular conformation
  • Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules
  • Light scattering and biomacromolecular conformation
  • Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products
  • Near-infrared spectroscopy and macromolecular conformation
  • Use of mid-infrared and Fourier transform infrared spectroscopy to study conformation of biomacromolecules
  • Use of Raman spectroscopy to evaluate biopharmaceutical conformation
  • The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products
  • Use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation
  • Use of nuclear magnetic resonance for the characterization of biotherapeutic products
  • Use of chemical probes for the study of protein conformation
  • Use of hydrogen exchange in the study of biopharmaceutical conformation
  • Use of chemical modification for the conformational analysis of biopharmaceuticals
  • Use of immunology to characterize biopharmaceutical conformation
  • Use of limited proteolysis to study the conformation of proteins of biotechnological interest
  • Other technologies for the characterization of conformational change in biopharmaceuticals
  • Development of an experimental approach for the study of the conformation of a biological therapeutic product.

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