Post-Translational Modifications in Health and Disease
Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cel...
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| Natura: | Elettronico eBook |
| Lingua: | English |
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New York, NY :
Springer New York : Imprint: Springer,
2011.
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| Edizione: | 1st ed. 2011. |
| Serie: | Protein Reviews ;
13 |
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| Accesso online: | https://doi.org/10.1007/978-1-4419-6382-6 |
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| Riassunto: | Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine. |
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| Descrizione fisica: | XIV, 490 p. online resource. |
| ISBN: | 9781441963826 |