Mitochondrial DNA, Mitochondria, Disease and Stem Cells
This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication an...
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| Other Authors: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2013.
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| Edition: | 1st ed. 2013. |
| Series: | Stem Cell Biology and Regenerative Medicine,
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| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-1-62703-101-1 |
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| LEADER | 03819nam a22005175i 4500 | ||
|---|---|---|---|
| 001 | 978-1-62703-101-1 | ||
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| 245 | 1 | 0 | |a Mitochondrial DNA, Mitochondria, Disease and Stem Cells |h [electronic resource] / |c edited by Justin C. St. John. |
| 250 | |a 1st ed. 2013. | ||
| 264 | 1 | |a Totowa, NJ : |b Humana Press : |b Imprint: Humana, |c 2013. | |
| 300 | |a X, 190 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Stem Cell Biology and Regenerative Medicine, |x 2196-8985 | |
| 505 | 0 | |a Clinical Approach to the Diagnosis of Mitochondrial Disease -- Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease -- Embryonic Stem Cells: A Signalling Perspective -- From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) A Mitochondrial Odyssey -- From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases -- The Role of Mitochondrial DNA in Tumor Cells -- Assisted Reproductive Technologies to Prevent the Transmission of mtDNA from one Generation to the Next. | |
| 520 | |a This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next. | ||
| 650 | 0 | |a Stem cells. | |
| 650 | 0 | |a Cell biology. | |
| 650 | 0 | |a Cell physiology. | |
| 650 | 1 | 4 | |a Stem Cells. |0 https://scigraph.springernature.com/ontologies/product-market-codes/L16010 |
| 650 | 2 | 4 | |a Cell Biology. |0 https://scigraph.springernature.com/ontologies/product-market-codes/L16008 |
| 650 | 2 | 4 | |a Cell Physiology. |0 https://scigraph.springernature.com/ontologies/product-market-codes/L33010 |
| 700 | 1 | |a St. John, Justin C. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9781627031028 |
| 776 | 0 | 8 | |i Printed edition: |z 9781627038676 |
| 776 | 0 | 8 | |i Printed edition: |z 9781627031004 |
| 830 | 0 | |a Stem Cell Biology and Regenerative Medicine, |x 2196-8985 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-1-62703-101-1 |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||