Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. T...
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| Hoofdauteurs: | , |
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| Coauteur: | |
| Formaat: | Elektronisch E-boek |
| Taal: | English |
| Gepubliceerd in: |
Cham :
Springer International Publishing : Imprint: Springer,
2015.
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| Editie: | 1st ed. 2015. |
| Reeks: | Advances in Anatomy, Embryology and Cell Biology,
215 |
| Onderwerpen: | |
| Online toegang: | https://doi.org/10.1007/978-3-319-12679-1 |
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| 001 | 978-3-319-12679-1 | ||
| 003 | DE-He213 | ||
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| 024 | 7 | |a 10.1007/978-3-319-12679-1 |2 doi | |
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| 100 | 1 | |a Braak, Heiko. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 245 | 1 | 0 | |a Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |h [electronic resource] / |c by Heiko Braak, Kelly Del Tredici. |
| 250 | |a 1st ed. 2015. | ||
| 264 | 1 | |a Cham : |b Springer International Publishing : |b Imprint: Springer, |c 2015. | |
| 300 | |a XI, 162 p. 48 illus., 44 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Advances in Anatomy, Embryology and Cell Biology, |x 0301-5556 ; |v 215 | |
| 505 | 0 | |a Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. . | |
| 520 | |a As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail. | ||
| 650 | 0 | |a Neurosciences. | |
| 650 | 0 | |a Pathology. | |
| 650 | 0 | |a Geriatrics. | |
| 650 | 1 | 4 | |a Neurosciences. |0 https://scigraph.springernature.com/ontologies/product-market-codes/B18006 |
| 650 | 2 | 4 | |a Pathology. |0 https://scigraph.springernature.com/ontologies/product-market-codes/H4800X |
| 650 | 2 | 4 | |a Geriatrics/Gerontology. |0 https://scigraph.springernature.com/ontologies/product-market-codes/H33150 |
| 700 | 1 | |a Del Tredici, Kelly. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783319126784 |
| 776 | 0 | 8 | |i Printed edition: |z 9783319126807 |
| 830 | 0 | |a Advances in Anatomy, Embryology and Cell Biology, |x 0301-5556 ; |v 215 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-319-12679-1 |
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| 912 | |a ZDB-2-SXM | ||
| 950 | |a Medicine (SpringerNature-11650) | ||
| 950 | |a Medicine (R0) (SpringerNature-43714) | ||