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Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. T...

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Bibliographic Details
Main Authors: Braak, Heiko. (Author, http://id.loc.gov/vocabulary/relators/aut), Del Tredici, Kelly. (http://id.loc.gov/vocabulary/relators/aut)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
Edition:1st ed. 2015.
Series:Advances in Anatomy, Embryology and Cell Biology, 215
Subjects:
Online Access:https://doi.org/10.1007/978-3-319-12679-1
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Table of Contents:
  • Prologue
  • General Morphology of Alzheimer-associated intraneuronal pathology
  • Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible
  • Basic organization of involved structures
  • Presymptomatic stages
  • General morphology of Alzheimer-associated extracellular pathology
  • Symptomatic stages
  • The progression of cortical lesions mimics the pattern of myelination in reverse order
  • Tauopathies
  • CSF biomarkers and imaging techniques
  • The staging hypothesis: assumptions, challenges, potential
  • Technical considerations.   .