Protein-Protein Interactions as New Drug Targets
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effec...
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| 企业作者: | |
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| 其他作者: | , |
| 格式: | 电子 电子书 |
| 语言: | English |
| 出版: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2008.
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| 版: | 1st ed. 2008. |
| 丛编: | Handbook of Experimental Pharmacology,
186 |
| 主题: | |
| 在线阅读: | https://doi.org/10.1007/978-3-540-72843-6 |
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书本目录:
- Organization of Scaffolds
- A-Kinase Anchoring Proteins as the Basis for cAMP Signaling
- Arrestins as Multi-Functional Signaling Adaptors
- Role of Ena/VASP Proteins in Homeostasis and Disease
- Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy
- Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?
- Scaffolding Proteins and Cellular Signalling
- PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases
- G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains
- Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design
- Compartmentalised MAPK Pathways
- Dynamic Protein Complexes Regulate NF-?B Signaling
- An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics
- A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling
- Cell Type-Specific Anchoring
- Scaffolding Proteins in Cardiac Myocytes
- Molecular Architecture of Signal Complexes Regulating Immune Cell Function
- Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework
- Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept
- Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies
- Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition
- Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors
- Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs
- Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets.