An updated overview of cyanidins for chemoprevention and cancer therapy
Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The most common and abundant anthocyanins are those presenting an O-glycosylation...
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Elsevier
2023
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oai:psasir.upm.edu.my:106624 http://psasir.upm.edu.my/id/eprint/106624/ An updated overview of cyanidins for chemoprevention and cancer therapy Posadino, Anna Maria Giordo, Roberta Ramli, Iman Zayed, Hatem Nasrallah, Gheyath K. Wehbe, Zena Eid, Ali H. Gürer, Eda Sönmez Kennedy, John F. Aldahish, Afaf Ahmed Calina, Daniela Razis, Ahmad Faizal Abdull Modu, Babagana Habtemariam, Solomon Sharifi-Rad, Javad Pintus, Gianfranco Cho, William C. Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The most common and abundant anthocyanins are those presenting an O-glycosylation at C-3 (C ring) of the flavonoid skeleton to form -O-²-glucoside derivatives. The present comprehensive review summarized recent data on the anticancer properties of cyanidings along with natural sources, phytochemical data, traditional medical applications, molecular mechanisms and recent nanostrategies to increase the bioavailability and anticancer effects of cyanidins. For this analysis, in vitro, in vivo and clinical studies published up to the year 2022 were sourced from scientific databases and search engines such as PubMed/Medline, Google scholar, Web of Science, Scopus, Wiley and TRIP database. Cyanidins antitumor properties are exerted during different stages of carcinogenesis and are based on a wide variety of biological activities. The data gathered and discussed in this review allows for affirming that cyanidins have relevant anticancer activity in vitro, in vivo and clinical studies. Future research should focus on studies that bring new data on improving the bioavailability of anthocyanins and on conducting detailed translational pharmacological studies to accurately establish the effective anticancer dose in humans as well as the correct route of administration. Elsevier 2023 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/106624/1/106624.pdf Posadino, Anna Maria and Giordo, Roberta and Ramli, Iman and Zayed, Hatem and Nasrallah, Gheyath K. and Wehbe, Zena and Eid, Ali H. and Gürer, Eda Sönmez and Kennedy, John F. and Aldahish, Afaf Ahmed and Calina, Daniela and Razis, Ahmad Faizal Abdull and Modu, Babagana and Habtemariam, Solomon and Sharifi-Rad, Javad and Pintus, Gianfranco and Cho, William C. (2023) An updated overview of cyanidins for chemoprevention and cancer therapy. Biomedicine & Pharmacotherapy, 163. art. no. 114783. pp. 1-18. ISSN 0753-3322; eISSN: 1950-6007 https://www.sciencedirect.com/science/article/pii/S0753332223005723?via%3Dihub 10.1016/j.biopha.2023.114783 |
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Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The most common and abundant anthocyanins are those presenting an O-glycosylation at C-3 (C ring) of the flavonoid skeleton to form -O-²-glucoside derivatives. The present comprehensive review summarized recent data on the anticancer properties of cyanidings along with natural sources, phytochemical data, traditional medical applications, molecular mechanisms and recent nanostrategies to increase the bioavailability and anticancer effects of cyanidins. For this analysis, in vitro, in vivo and clinical studies published up to the year 2022 were sourced from scientific databases and search engines such as PubMed/Medline, Google scholar, Web of Science, Scopus, Wiley and TRIP database. Cyanidins antitumor properties are exerted during different stages of carcinogenesis and are based on a wide variety of biological activities. The data gathered and discussed in this review allows for affirming that cyanidins have relevant anticancer activity in vitro, in vivo and clinical studies. Future research should focus on studies that bring new data on improving the bioavailability of anthocyanins and on conducting detailed translational pharmacological studies to accurately establish the effective anticancer dose in humans as well as the correct route of administration. |
| format |
Article |
| author |
Posadino, Anna Maria Giordo, Roberta Ramli, Iman Zayed, Hatem Nasrallah, Gheyath K. Wehbe, Zena Eid, Ali H. Gürer, Eda Sönmez Kennedy, John F. Aldahish, Afaf Ahmed Calina, Daniela Razis, Ahmad Faizal Abdull Modu, Babagana Habtemariam, Solomon Sharifi-Rad, Javad Pintus, Gianfranco Cho, William C. |
| spellingShingle |
Posadino, Anna Maria Giordo, Roberta Ramli, Iman Zayed, Hatem Nasrallah, Gheyath K. Wehbe, Zena Eid, Ali H. Gürer, Eda Sönmez Kennedy, John F. Aldahish, Afaf Ahmed Calina, Daniela Razis, Ahmad Faizal Abdull Modu, Babagana Habtemariam, Solomon Sharifi-Rad, Javad Pintus, Gianfranco Cho, William C. An updated overview of cyanidins for chemoprevention and cancer therapy |
| author_facet |
Posadino, Anna Maria Giordo, Roberta Ramli, Iman Zayed, Hatem Nasrallah, Gheyath K. Wehbe, Zena Eid, Ali H. Gürer, Eda Sönmez Kennedy, John F. Aldahish, Afaf Ahmed Calina, Daniela Razis, Ahmad Faizal Abdull Modu, Babagana Habtemariam, Solomon Sharifi-Rad, Javad Pintus, Gianfranco Cho, William C. |
| author_sort |
Posadino, Anna Maria |
| title |
An updated overview of cyanidins for chemoprevention and cancer therapy |
| title_short |
An updated overview of cyanidins for chemoprevention and cancer therapy |
| title_full |
An updated overview of cyanidins for chemoprevention and cancer therapy |
| title_fullStr |
An updated overview of cyanidins for chemoprevention and cancer therapy |
| title_full_unstemmed |
An updated overview of cyanidins for chemoprevention and cancer therapy |
| title_sort |
updated overview of cyanidins for chemoprevention and cancer therapy |
| publisher |
Elsevier |
| publishDate |
2023 |
| url |
http://psasir.upm.edu.my/id/eprint/106624/1/106624.pdf |
| _version_ |
1819301695517097984 |
| score |
13.4562235 |