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Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity

Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine an...

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Main Authors:	Baharuddin, Fatin Farhana, Mad Nasir, Nadiah, Tejo, Bimo Ario, Koh, Soo Peng, Ramakrishnan, Shuruti, Nordin, Nur Qurratu Ain A., Adzahar, Anis Nasuha, Devakrishnan, Pavithren, Mohd Razib, Salsabiilaa
Format:	Article
Published:	Taylor and Francis Group 2023
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id	oai:psasir.upm.edu.my:108720
record_format	eprints
spelling	oai:psasir.upm.edu.my:108720 http://psasir.upm.edu.my/id/eprint/108720/ Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine and L-DOPA substrates, while compound 13 showed high inhibition (96.0% and 62.0%) for both substrates. Molecular docking simulations revealed compounds 11 and 13 bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry. Taylor and Francis Group 2023-10-05 Article PeerReviewed Baharuddin, Fatin Farhana and Mad Nasir, Nadiah and Tejo, Bimo Ario and Koh, Soo Peng and Ramakrishnan, Shuruti and Nordin, Nur Qurratu Ain A. and Adzahar, Anis Nasuha and Devakrishnan, Pavithren and Mohd Razib, Salsabiilaa (2023) Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity. Journal of Asian Natural Products Research, 26 (5). pp. 575-582. ISSN 1028-6020; ESSN: 1477-2213 https://www.tandfonline.com/doi/full/10.1080/10286020.2023.2264784 10.1080/10286020.2023.2264784
institution	UPM IR
collection	UPM IR
description	Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine and L-DOPA substrates, while compound 13 showed high inhibition (96.0% and 62.0%) for both substrates. Molecular docking simulations revealed compounds 11 and 13 bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry.
format	Article
author	Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa
spellingShingle	Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
author_facet	Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa
author_sort	Baharuddin, Fatin Farhana
title	Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
title_short	Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
title_full	Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
title_fullStr	Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
title_full_unstemmed	Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
title_sort	potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
publisher	Taylor and Francis Group
publishDate	2023
_version_	1819301821765648384
score	13.4562235

Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity

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