Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of...
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Frontiers Media
2023
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oai:psasir.upm.edu.my:109427 http://psasir.upm.edu.my/id/eprint/109427/ Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents Peña-Corona, Sheila I. Hernández-Parra, Héctor Bernal-Chávez, Sergio A. Mendoza-Muñoz, Néstor Romero-Montero, Alejandra Del Prado-Audelo, María Luisa Cortés, Hernán Ateşşahin, Dilek Arslan Habtemariam, Solomon Almarhoon, Zainab M. Abdull Razis, Ahmad Faizal Modu, Babagana Sharifi-Rad, Javad Leyva-Gómez, Gerardo Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of potency due to increased resistance. As a result, one of the current approaches is on with the search of bioactive anticancer compounds from natural sources. Neopeltolide is a marine-derived macrolide isolated from deep-water sponges collected off Jamaica’s north coast. Its mechanism of action is still under research but represents a potentially promising novel drug for cancer therapy. In this review, we first illustrate the general structural characterization of neopeltolide, the semi-synthetic derivatives, and current medical applications. In addition, we reviewed its anticancer properties, primarily based on in vitro studies, and the possible clinical trials. Finally, we summarize the recent progress in the mechanism of antitumor action of neopeltolide. According to the information presented, we identified two principal challenges in the research, i) the effective dose which acts neopeltolide as an anticancer compound, and ii) to unequivocally establish the mechanism of action by which the compound exerts its antiproliferative effect. Frontiers Media 2023-06-06 Article PeerReviewed Peña-Corona, Sheila I. and Hernández-Parra, Héctor and Bernal-Chávez, Sergio A. and Mendoza-Muñoz, Néstor and Romero-Montero, Alejandra and Del Prado-Audelo, María Luisa and Cortés, Hernán and Ateşşahin, Dilek Arslan and Habtemariam, Solomon and Almarhoon, Zainab M. and Abdull Razis, Ahmad Faizal and Modu, Babagana and Sharifi-Rad, Javad and Leyva-Gómez, Gerardo (2023) Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents. Frontiers in Pharmacology, 14. pp. 1-10. ISSN 1663-9812 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1206334/full 10.3389/fphar.2023.1206334 |
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Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of potency due to increased resistance. As a result, one of the current approaches is on with the search of bioactive anticancer compounds from natural sources. Neopeltolide is a marine-derived macrolide isolated from deep-water sponges collected off Jamaica’s north coast. Its mechanism of action is still under research but represents a potentially promising novel drug for cancer therapy. In this review, we first illustrate the general structural characterization of neopeltolide, the semi-synthetic derivatives, and current medical applications. In addition, we reviewed its anticancer properties, primarily based on in vitro studies, and the possible clinical trials. Finally, we summarize the recent progress in the mechanism of antitumor action of neopeltolide. According to the information presented, we identified two principal challenges in the research, i) the effective dose which acts neopeltolide as an anticancer compound, and ii) to unequivocally establish the mechanism of action by which the compound exerts its antiproliferative effect. |
| format |
Article |
| author |
Peña-Corona, Sheila I. Hernández-Parra, Héctor Bernal-Chávez, Sergio A. Mendoza-Muñoz, Néstor Romero-Montero, Alejandra Del Prado-Audelo, María Luisa Cortés, Hernán Ateşşahin, Dilek Arslan Habtemariam, Solomon Almarhoon, Zainab M. Abdull Razis, Ahmad Faizal Modu, Babagana Sharifi-Rad, Javad Leyva-Gómez, Gerardo |
| spellingShingle |
Peña-Corona, Sheila I. Hernández-Parra, Héctor Bernal-Chávez, Sergio A. Mendoza-Muñoz, Néstor Romero-Montero, Alejandra Del Prado-Audelo, María Luisa Cortés, Hernán Ateşşahin, Dilek Arslan Habtemariam, Solomon Almarhoon, Zainab M. Abdull Razis, Ahmad Faizal Modu, Babagana Sharifi-Rad, Javad Leyva-Gómez, Gerardo Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents |
| author_facet |
Peña-Corona, Sheila I. Hernández-Parra, Héctor Bernal-Chávez, Sergio A. Mendoza-Muñoz, Néstor Romero-Montero, Alejandra Del Prado-Audelo, María Luisa Cortés, Hernán Ateşşahin, Dilek Arslan Habtemariam, Solomon Almarhoon, Zainab M. Abdull Razis, Ahmad Faizal Modu, Babagana Sharifi-Rad, Javad Leyva-Gómez, Gerardo |
| author_sort |
Peña-Corona, Sheila I. |
| title |
Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents |
| title_short |
Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents |
| title_full |
Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents |
| title_fullStr |
Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents |
| title_full_unstemmed |
Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents |
| title_sort |
neopeltolide and its synthetic derivatives: a promising new class of anticancer agents |
| publisher |
Frontiers Media |
| publishDate |
2023 |
| _version_ |
1819301881338396672 |
| score |
13.4562235 |