C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Asian Network for Scientific Information
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13469/1/C511T%20polymorphism%20of%20interleukin1%20%CE%B2%20gene%20is%20not%20associated%20in%20type%202%20diabetes%20mellitus%20%20a%20study%20in%20Malaysian%20population.pdf |
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| Summary: | The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population. |
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