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C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.

The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP a...

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Asıl Yazarlar: Vasudevan, Ramachandran, Ismail, Patimah, Stanslas, Johnson, Shamsudin, Norashikin
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Asian Network for Scientific Information 2008
Online Erişim:http://psasir.upm.edu.my/id/eprint/13469/1/C511T%20polymorphism%20of%20interleukin1%20%CE%B2%20gene%20is%20not%20associated%20in%20type%202%20diabetes%20mellitus%20%20a%20study%20in%20Malaysian%20population.pdf
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spelling oai:psasir.upm.edu.my:13469 http://psasir.upm.edu.my/id/eprint/13469/ C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population. Asian Network for Scientific Information 2008-04-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13469/1/C511T%20polymorphism%20of%20interleukin1%20%CE%B2%20gene%20is%20not%20associated%20in%20type%202%20diabetes%20mellitus%20%20a%20study%20in%20Malaysian%20population.pdf Vasudevan, Ramachandran and Ismail, Patimah and Stanslas, Johnson and Shamsudin, Norashikin (2008) C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. Journal of Medical Sciences, 8 (3). pp. 216-221. ISSN 1682-4474; ESSN : 1812-5727 http://scialert.net/abstract/?doi=jms.2008.216.221 10.3923/jms.2008.216.221
institution UPM IR
collection UPM IR
language English
description The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population.
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author Vasudevan, Ramachandran
Ismail, Patimah
Stanslas, Johnson
Shamsudin, Norashikin
spellingShingle Vasudevan, Ramachandran
Ismail, Patimah
Stanslas, Johnson
Shamsudin, Norashikin
C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
author_facet Vasudevan, Ramachandran
Ismail, Patimah
Stanslas, Johnson
Shamsudin, Norashikin
author_sort Vasudevan, Ramachandran
title C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
title_short C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
title_full C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
title_fullStr C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
title_full_unstemmed C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.
title_sort c-511t polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in malaysian population.
publisher Asian Network for Scientific Information
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/13469/1/C511T%20polymorphism%20of%20interleukin1%20%CE%B2%20gene%20is%20not%20associated%20in%20type%202%20diabetes%20mellitus%20%20a%20study%20in%20Malaysian%20population.pdf
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score 12.933938

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