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Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery

Despite the progress made in cancer treatment, difficulties are encountered with tumour targeting due to cancer structural complexity. The synthesis of homogenous calcium carbonate (CaCO3) nanoparticles could be a carrier for doxorubicin in the management of bone cancer due to its osteoconductive an...

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Main Authors: Danmaigoro, Abubakar, Selvarajah, Gayathri Thevi, Mohd Noor, Mohd Hezmee, Mahmud, Rozi, Abu Bakar @ Zakaria, Md Zuki
Format: Article
Language:English
Published: American Scientific Publishers 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61454/1/Development%20of%20cockleshell%20.pdf
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spelling oai:psasir.upm.edu.my:61454 http://psasir.upm.edu.my/id/eprint/61454/ Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery Danmaigoro, Abubakar Selvarajah, Gayathri Thevi Mohd Noor, Mohd Hezmee Mahmud, Rozi Abu Bakar @ Zakaria, Md Zuki Despite the progress made in cancer treatment, difficulties are encountered with tumour targeting due to cancer structural complexity. The synthesis of homogenous calcium carbonate (CaCO3) nanoparticles could be a carrier for doxorubicin in the management of bone cancer due to its osteoconductive and physicochemical properties with simple synthesis method to produce large scale. Among the nanocarriers, CaCO3 nanoparticles have exhibited promising potential as targeting drug nanocarrier. The aim of this study is to synthesised and characterised doxorubicin-conjugated CaCO3 nanoparticle (CS-CaCO3NP-DOX), using a simple precipitation and mechanical approach to synthesise homogeneous CaCO3NP from cockleshell. The oven-dried nanoparticles were further characterised for its physicochemical properties before and after conjugating with doxorubicin. A homogenous aragonite, spherical, porous nanocarrier was obtained with a mean diameter of 24.9 nm and zeta potential of –21 mV. The energy dispersion X-ray analysis revealed high proportion of calcium as a major element in the nanoparticle. The spectrum peak suggests little alteration upon incorporation of doxorubicin. Higher loading content and encapsulation efficiency were recorded with CS-CaCO3NP. These properties underscore the potential of CS-CaCO3NP in the delivery of doxorubicin, thus giving it a high potential for application in the delivery of the anticancer in the management of cancers. American Scientific Publishers 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61454/1/Development%20of%20cockleshell%20.pdf Danmaigoro, Abubakar and Selvarajah, Gayathri Thevi and Mohd Noor, Mohd Hezmee and Mahmud, Rozi and Abu Bakar @ Zakaria, Md Zuki (2017) Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery. Journal of Computational and Theoretical Nanoscience, 14 (10). pp. 5074-5086. ISSN 1546-1955; ESSN: 1546-1963 http://www.ingentaconnect.com/content/asp/jctn/2017/00000014/00000010/art00041 10.1166/jctn.2017.6920
institution UPM IR
collection UPM IR
language English
description Despite the progress made in cancer treatment, difficulties are encountered with tumour targeting due to cancer structural complexity. The synthesis of homogenous calcium carbonate (CaCO3) nanoparticles could be a carrier for doxorubicin in the management of bone cancer due to its osteoconductive and physicochemical properties with simple synthesis method to produce large scale. Among the nanocarriers, CaCO3 nanoparticles have exhibited promising potential as targeting drug nanocarrier. The aim of this study is to synthesised and characterised doxorubicin-conjugated CaCO3 nanoparticle (CS-CaCO3NP-DOX), using a simple precipitation and mechanical approach to synthesise homogeneous CaCO3NP from cockleshell. The oven-dried nanoparticles were further characterised for its physicochemical properties before and after conjugating with doxorubicin. A homogenous aragonite, spherical, porous nanocarrier was obtained with a mean diameter of 24.9 nm and zeta potential of –21 mV. The energy dispersion X-ray analysis revealed high proportion of calcium as a major element in the nanoparticle. The spectrum peak suggests little alteration upon incorporation of doxorubicin. Higher loading content and encapsulation efficiency were recorded with CS-CaCO3NP. These properties underscore the potential of CS-CaCO3NP in the delivery of doxorubicin, thus giving it a high potential for application in the delivery of the anticancer in the management of cancers.
format Article
author Danmaigoro, Abubakar
Selvarajah, Gayathri Thevi
Mohd Noor, Mohd Hezmee
Mahmud, Rozi
Abu Bakar @ Zakaria, Md Zuki
spellingShingle Danmaigoro, Abubakar
Selvarajah, Gayathri Thevi
Mohd Noor, Mohd Hezmee
Mahmud, Rozi
Abu Bakar @ Zakaria, Md Zuki
Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery
author_facet Danmaigoro, Abubakar
Selvarajah, Gayathri Thevi
Mohd Noor, Mohd Hezmee
Mahmud, Rozi
Abu Bakar @ Zakaria, Md Zuki
author_sort Danmaigoro, Abubakar
title Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery
title_short Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery
title_full Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery
title_fullStr Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery
title_full_unstemmed Development of cockleshell (Anadara granosa) derived CaCO3 nanoparticle for doxorubicin delivery
title_sort development of cockleshell (anadara granosa) derived caco3 nanoparticle for doxorubicin delivery
publisher American Scientific Publishers
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/61454/1/Development%20of%20cockleshell%20.pdf
_version_ 1819298110459871232
score 13.4562235

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